Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH31BC)

• DME Name: Hyaluronate lyase (hyaL)
• Synonyms: Alginate lyase; Poly-beta-D-glucuronate lyase; Endolytic polysaccharide lyase; Multifunctional polysaccharide lyase; Polysaccharide lyase; PL; Smon_0117
• Gene Name: hyaL
• UniProt ID: D1AWD4_STRM9
• INTEDE ID: DME1240
• Gene ID: 29673833
• EC Number:
  EC: 4.2.2.1
  Lyases
  Carbon-oxygen lyase
  Polysaccharide-lyase
  EC: 4.2.2.1
• Lineage:
  Species: Streptobacillus moniliformis
  Kingdom: Bacteria
  Phylum: Fusobacteria
  Class: Fusobacteriia
  Order: Fusobacteriales
  Family: Leptotrichiaceae
  Genus: Streptobacillus
  Species: Streptobacillus moniliformis
• Tissue Distribution: Primarily distributed in human blood.
• Sequence:
  MYELLLKRREYLIGNFKDLPLNKRKQIEEIQEKNIEKLEYLENLNIAEVKLKYNNILELA
  KAYNQVGNVRYRDEKIKVIILKTLKLLRITYYNLSSVEKVNWWQWEIGIPLLLNDIFILM
  NEKDFDFEKEENLKTSIYFQKDPRYSGNNPVATHPSKKPFRISTGGNRVDTVKVSLFRSI
  LLNNEEELKLALNSLPEVWKCREKINRIETDTQRDGFYNDGSFIQHGSLAYNGTYGNVLL
  QGIGEILYVIGDSKYLKYLGDIYSLKDIILNSYKPFMYKGSFPDMLNGRAITRENSSDKT
  IGHMLLNSIMLISCGLNDEELKNLVASEILKYEDYSYFDKELSPFMYDLVKKNIHNRKKE
  EYGKIIKVSNIMNRVFIKDDKKAIAIAGHSENISNYESINGENTKGWYTGDGMIYLYTSD
  VTYTNYWNNSDTRYMSGTTEVYEDLNGINTSQILNVNMSSAKIVKAIEKDNKMIFFMEFE
  NHNKSLKMYKSYVYTGKKLICLNTNIDTKEKIYTTIDNRLYKEKPKIVMEDKRILINDLI
  FNIITDHKFNFDIKESEFGYFVKIWIEHKYNENLYYEIIFEYDDKTSLIEDNKENIIIRN
  GNEKYLINTKEKEVLRFE
• Function: This enzyme catalyzes the degradation of hyaluronan by a beta-elimination reaction and it also acts on chondroitin.

Molecular Interaction Atlas (MIA) of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hyaluronate sodium	DMX8M26	Joint lubricant	FA30-FA38	Approved	[1]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[1], [2]

References

• [1] A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
• [2] A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports