General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH3ABM)

DME Name Nitroreductase (NTR)
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; DCW51_03155
Gene Name DCW51_03155
UniProt ID
A0A351QTB1_CLOSP
INTEDE ID
DME1246
EC Number EC: 1.5.1.39
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage Species: Clostridium hiranonis
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptostreptococcaceae
Genus: Clostridium
Species: Clostridium hiranonis
Tissue Distribution Primarily distributed in human gut.
Sequence
MNKEYLNDTIKLLCERASCRSFLDKKIPDELLNEIISCGLHAATGGNLQPYSIIKITDDK
TKERLVNECDMQSLVKNAPVNLLFCIDWRRIQRWCEASDAPFVATKSYRHFWIALQDTII
CAQNICTAADSIGLGSVYIGTVESCFMELKSIFNIPEGVFPVVLLSIGYPNQPLIPAPKL
GIEAIVHEESYKDLTIDTLVKLQNEKYNSKKFPLSPTNTASMKEVTLDIGGEDYSNKIIT
SIEQQGYINMAQRYFGLHYKANWSCIGNKNFIEALKAYGFTWIMGEDFPTGDK
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [1]
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
P-nitrobenzoic acid DMVJUOZ N. A. N. A. Investigative [1]

References

1 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.