Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEHDW40)

DME Name	Cytochrome P450 154C2 (cyp154)
Synonyms	Cytochrome P450 family 154 subfamily C member 2; Cytochrome cyp154C2; P450 154C2; cyp154C2
Gene Name	cyp154C4-2
UniProt ID	A0A345AH95_STRSQ
INTEDE ID	DME1466
EC Number	EC: 1.14.14.1 Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Streptomyces avermitilis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces avermitilis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTRIALDPFVRDLDGESAALRAAGPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDIN VWNAWQRGEIPADWPLIGLVNPGRSMLTVDGPDHRRLRTLVAQALTVKRVEKLRAGIEAL TNASLERLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPP EEVPQMMADLGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGH ETTISLIVNVVEALAIHPEQRKKVLSGEIPWEGVIEETLRWNTPTSHVLIRFATEDIEVG DKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPNRHIAFGHGPHVCPGAALSRLEA GIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPVKLGCPFGHDA
Function	This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[1], [2]
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References

1	Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
2	The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.