Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIEY19)

• DME Name: Beta-galactosidase (bgaB)
• Synonyms: Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; ESA_02977; Lactase; lacZ
• Gene Name: lacZ
• UniProt ID: BGAL_CROS8
• INTEDE ID: DME2059
• EC Number:
  EC: 3.2.1.23
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.23
• Lineage:
  Species: Cronobacter sakazakii
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Cronobacter
  Species: Cronobacter sakazakii
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTENPTTTAFNELQTRPLATILARNDWQNPAITSVNRLPSHTPLHGWRDADRARRGEPSD
  AVLSLDGEWQFSFFASPHQVPEVWLAADLSDARATPVPSNWQMEGYDTPIYTNVRYPIPV
  NPPFVPDDNPTGCYSRDIEVPQAWLETGRTRIIFGGVNSAFYLWCNGQWVGYSQDSRLPA
  EFDLTGVLHAGRNRLCVLVLRWSDGTYLEDQDMWRMSGIFRPVSLLHLPEQALADVRVHT
  ELAPSLRHATLFSEVEVTPAACGLSVTLALWHGENEIASQTLPLGSAPIDERGNYAERVT
  LSLDVDNPLLWSAETPHLYRAVVTLLDADGMPLVSEAHDVGFRRVEINNGLLTLNGQPLL
  IRGVNRHEHHPEKGQAVDEAAMVQDILLMKQNNFNAVRCSHYPNQPRWYELCSRYGLYVV
  DEANIETHGMEPMSRLSDDPVWLGAYSERVTRMVKCNRNHPSIIIWSLGNESGNGATHTA
  LYNWIKHQDPTRPVQYEGGGADTRATDIICPMYARVETDQLIPAVPKWSIKKWISMPGET
  RPLILCEYAHAMGNSLGNFADYWAAFRQYPRLQGGFIWDWADQAITRVEPDGSRWWAYGG
  DFGDTPNDRQFCMNGLVFPDRTPHPALFEAKHQQQFFQFRLVSENPLQIEVTSEYLFRES
  DNERLLWSIEVRGETRLSGELTLELGPQASRVLTLSDTGFSARAGDEEIWLHVRVEQPQA
  TPWSPEGHLSAWAQWPLAAPLALPEPVAAGDAPQLEITDAEFVIRHGCQTWRVSRASGQL
  IQWSDDGVDQILTPLADQFIRAPIDNDIGVSEVERIDPNAWVERWKAAGLYNTEHRCLAC
  DAQTTRDGVEIVAQHAYFVKGVADGPAILSRWRMVVDNQGALHCDIDIARSAALPPLPRV
  GVVCQLRGGEETASWLGLGPHENYPDRLSSACFSRWTLPLSELTTPYIFPGENGLRCNTR
  ELNWNGWQAEGEFHFSLSPYGTRQLMETSHWHKLQPEAGIWLTIDGFHMGVGGDDSWTPS
  VHPEYLLTAREYRYRFTLRRRQG
• Function: This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.
• KEGG Pathway:
  Galactose metabolism (esa00052)
  Metabolic pathways (esa01100)
  Other glycan degradation (esa00511)
  Sphingolipid metabolism (esa00600)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lactulose	DMSAOWQ	Constipation	DD91.1	Approved	[1]

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[2]

References

• [1] In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.
• [2] In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.