Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIKZOU)

DME Name	Azoreductase (azoR)
Synonyms	Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; BSIG_4687; Btheta7330_01816
Gene Name	azoR
UniProt ID	A0A0P0ETC6_BACT4
INTEDE ID	DME1473
EC Number	EC: 1.7.1.6 Oxidoreductase Cytochrome acceptor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.7.1.6
Lineage	Species: Bacteroides fragilis Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides fragilis Subspecies: Bacteroides fragilis str. 3397 T10
Tissue Distribution	Primarily distributed in human gut.
Sequence	MDRKGFLKSTMIATGSLLLGGAGICRFLNDKEPADGPFPRTIEKIHCGNMKKVLVIMSAG TKLGNTDRLTDAYIKGLVERGHSVTKVYLGSMRIEGCRGCGVCQRLAHQCAVRDGMQDIY PLFAECDTVVMASPLYFWTITSQLKAFIDRLYAISADDKYPQKDTVLLMTAGDDNENTFD QPKQYFRLLSQALGWNEVGIYCAGGCTGCEKLARQIDKVHLENVYKMGLEL
Function	This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[1]
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References

1	Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.