Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIORCK)

DME Name Dipeptidyl peptidase II (DPP7)
Synonyms Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 2; Dipeptidyl peptidase 7; Quiescent cell proline dipeptidase; DPP II; DPP2; DPP7; QPP
Gene Name DPP7
UniProt ID
DPP2_HUMAN
INTEDE ID
DME0592
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
29952
EC Number EC: 3.4.14.2
Hydrolases
Peptidase
Di/tripeptidyl peptidase
EC: 3.4.14.2
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
Function This enzyme plays an important role in the degradation of some oligopeptides.
Reactome Pathway
Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
BRADYKININ DM4R6UV N. A. N. A. Phase 1 [4]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 3.64E-15 -5.17E-01 -9.98E-01
Alopecia ED70 Skin from scalp 3.54E-01 1.35E-01 3.03E-01
Alzheimer's disease 8A20 Entorhinal cortex 3.28E-06 -1.71E-01 -8.15E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 5.71E-01 1.54E-02 5.39E-02
Aortic stenosis BB70 Calcified aortic valve 5.88E-01 -2.50E-02 -5.10E-02
Apnea 7A40 Hyperplastic tonsil 3.71E-01 -1.19E-01 -8.84E-01
Arthropathy FA00-FA5Z Peripheral blood 1.12E-01 -3.32E-01 -1.05E+00
Asthma CA23 Nasal and bronchial airway 9.03E-04 -2.44E-01 -3.87E-01
Atopic dermatitis EA80 Skin 1.46E-02 2.81E-02 1.95E-01
Autism 6A02 Whole blood 9.79E-01 -2.82E-02 -9.25E-02
Autoimmune uveitis 9A96 Peripheral monocyte 8.67E-04 -1.43E-01 -8.18E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.37E-02 -1.15E-01 -6.31E-01
Bacterial infection of gingival 1C1H Gingival tissue 4.22E-01 -8.38E-02 -2.49E-01
Batten disease 5C56.1 Whole blood 4.55E-02 9.68E-02 1.46E+00
Behcet's disease 4A62 Peripheral blood 7.60E-01 2.40E-02 6.88E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.06E-01 -2.14E-03 -1.02E-02
Bladder cancer 2C94 Bladder tissue 7.53E-10 8.51E-01 5.47E+00
Breast cancer 2C60-2C6Z Breast tissue 1.14E-64 7.11E-01 1.42E+00
Cardioembolic stroke 8B11.20 Whole blood 3.44E-01 -8.48E-02 -2.17E-01
Cervical cancer 2C77 Cervical tissue 1.17E-03 -2.91E-01 -1.21E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.30E-01 -1.23E-01 -5.36E-01
Chronic hepatitis C 1E51.1 Whole blood 4.93E-02 -1.44E-01 -6.30E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.09E-01 9.74E-02 3.74E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.45E-01 1.97E-01 4.33E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.99E-01 3.55E-02 1.37E-01
Colon cancer 2B90 Colon tissue 9.28E-86 6.48E-01 2.51E+00
Coronary artery disease BA80-BA8Z Peripheral blood 6.33E-01 -3.05E-01 -3.90E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 1.71E-01 -1.83E-01 -2.56E-01
Endometriosis GA10 Endometrium tissue 9.94E-02 -9.24E-02 -4.02E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.82E-01 4.75E-02 2.96E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.27E-03 -2.78E-01 -7.91E-01
Gastric cancer 2B72 Gastric tissue 8.01E-01 -1.64E-01 -5.06E-01
Glioblastopma 2A00.00 Nervous tissue 2.50E-59 4.02E-01 1.17E+00
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 3.57E-01 6.36E-01 9.76E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 7.69E-03 6.23E-01 1.22E+00
Head and neck cancer 2D42 Head and neck tissue 7.63E-13 -3.83E-01 -3.16E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 7.07E-01 -1.77E-02 -8.89E-02
Huntington's disease 8A01.10 Whole blood 6.18E-02 -2.26E-01 -6.86E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.98E-01 4.20E-02 8.10E-02
Immunodeficiency 4A00-4A20 Peripheral blood 2.89E-01 -5.50E-02 -6.04E-01
Influenza 1E30 Whole blood 1.19E-01 -3.12E-01 -1.58E+00
Interstitial cystitis GC00.3 Bladder tissue 8.77E-02 1.66E-01 7.46E-01
Intracranial aneurysm 8B01.0 Intracranial artery 1.47E-03 4.37E-01 1.45E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.27E-01 -3.71E-02 -1.05E-01
Ischemic stroke 8B11 Peripheral blood 9.88E-02 1.59E-01 4.74E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.65E-01 1.35E-01 2.74E-01
Lateral sclerosis 8B60.4 Skin 4.13E-01 9.45E-02 2.51E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.43E-01 -5.97E-03 -2.74E-02
Liver cancer 2C12.0 Liver tissue 2.24E-05 1.75E-01 5.88E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.98E-01 2.16E-01 5.95E-01
Lung cancer 2C25 Lung tissue 5.22E-03 7.24E-02 1.41E-01
Lupus erythematosus 4A40 Whole blood 2.40E-01 -1.10E-01 -1.93E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.26E-01 6.94E-02 3.31E-01
Major depressive disorder 6A70-6A7Z Whole blood 2.01E-01 -1.52E-01 -4.97E-01
Melanoma 2C30 Skin 8.67E-01 1.18E-01 2.29E-01
Multiple myeloma 2A83.1 Peripheral blood 7.38E-01 6.72E-02 2.19E-01
Multiple myeloma 2A83.1 Bone marrow 3.72E-01 -7.08E-03 -6.14E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.79E-01 -5.72E-02 -9.67E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.18E-02 -1.71E-01 -3.49E-01
Myelofibrosis 2A20.2 Whole blood 1.54E-01 1.22E-01 8.39E-01
Myocardial infarction BA41-BA50 Peripheral blood 8.74E-01 -9.71E-02 -1.79E-01
Myopathy 8C70.6 Muscle tissue 1.21E-01 2.44E-01 7.71E-01
Neonatal sepsis KA60 Whole blood 7.67E-11 -2.95E-01 -1.03E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.13E-01 8.08E-02 1.56E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 5.66E-01 -8.12E-02 -5.19E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 3.97E-01 3.08E-02 1.19E-01
Olive pollen allergy CA08.00 Peripheral blood 5.29E-01 8.95E-02 1.68E-01
Oral cancer 2B6E Oral tissue 6.22E-02 -2.94E-01 -7.10E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.15E-01 7.90E-02 2.13E-01
Osteoporosis FB83.1 Bone marrow 8.12E-01 2.58E-02 1.48E-01
Ovarian cancer 2C73 Ovarian tissue 9.59E-01 -9.43E-02 -2.96E-01
Pancreatic cancer 2C10 Pancreas 2.52E-02 -1.97E-01 -3.91E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 1.07E-01 -1.91E-01 -4.80E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.91E-02 -2.71E-01 -9.19E-01
Pituitary cancer 2D12 Pituitary tissue 8.51E-01 -8.02E-02 -2.00E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.94E-03 5.63E-01 1.30E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.86E-01 -2.49E-02 -1.98E-01
Polycythemia vera 2A20.4 Whole blood 2.44E-01 -2.55E-03 -2.01E-02
Pompe disease 5C51.3 Biceps muscle 4.29E-02 -3.15E-01 -1.41E+00
Preterm birth KA21.4Z Myometrium 2.05E-01 1.22E-01 8.06E-01
Prostate cancer 2C82 Prostate 6.74E-03 2.58E-01 4.96E-01
Psoriasis EA90 Skin 4.68E-01 5.36E-02 9.83E-02
Rectal cancer 2B92 Rectal colon tissue 2.13E-04 3.63E-01 1.93E+00
Renal cancer 2C90-2C91 Kidney 1.71E-01 -4.01E-01 -8.82E-01
Retinoblastoma 2D02.2 Uvea 7.77E-06 -1.44E+00 -3.96E+00
Rheumatoid arthritis FA20 Synovial tissue 5.55E-01 2.66E-01 4.74E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.62E-01 -2.04E-01 -4.03E-01
Schizophrenia 6A20 Prefrontal cortex 2.19E-01 3.30E-02 1.24E-01
Schizophrenia 6A20 Superior temporal cortex 5.95E-01 -1.88E-02 -1.28E-01
Scleroderma 4A42.Z Whole blood 2.84E-01 7.69E-02 4.88E-01
Seizure 8A60-8A6Z Whole blood 2.38E-01 2.27E-02 1.06E-01
Sensitive skin EK0Z Skin 3.46E-01 1.33E-01 8.86E-01
Sepsis with septic shock 1G41 Whole blood 6.66E-05 -1.41E-01 -4.76E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.17E-03 -4.95E-01 -2.76E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.03E-01 -1.57E-01 -7.41E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 1.27E-01 -6.99E-01 -2.03E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.72E-01 -1.65E-01 -4.88E-01
Skin cancer 2C30-2C3Z Skin 2.53E-08 2.67E-01 4.99E-01
Thrombocythemia 3B63 Whole blood 9.49E-01 -4.37E-02 -3.10E-01
Thrombocytopenia 3B64 Whole blood 1.12E-01 7.71E-01 2.22E+00
Thyroid cancer 2D10 Thyroid 3.38E-20 -6.52E-01 -1.55E+00
Tibial muscular dystrophy 8C75 Muscle tissue 1.96E-09 1.03E+00 4.08E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.32E-01 -2.82E-01 -1.02E+00
Type 2 diabetes 5A11 Liver tissue 1.39E-01 -1.42E-01 -3.73E-01
Ureter cancer 2C92 Urothelium 8.06E-01 5.46E-02 1.55E-01
Uterine cancer 2C78 Endometrium tissue 3.29E-08 -3.80E-01 -8.38E-01
Vitiligo ED63.0 Skin 1.49E-02 3.29E-01 1.40E+00
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name Dipeptidyl-peptidase 7 (DPP7) DTT Info
DME DTT Type Patented-recorded
8 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
BDBM50382283 DMQJ5S8 N. A. N. A. Patented [1]
BDBM50434164 DM6DFTX N. A. N. A. Patented [1]
BDBM50434165 DMDTYJ9 N. A. N. A. Patented [1]
CRWCYVOHVXAEMF-LBPRGKRZSA-N DMBV5Z0 N. A. N. A. Patented [1]
US8470836, 2 DMH7JVA N. A. N. A. Patented [2]
US8470836, 5 DMYR10P N. A. N. A. Patented [2]
US8470836, 6 DMVYQXH N. A. N. A. Patented [2]
US8470836, 8 DMM4GLH N. A. N. A. Patented [2]
⏷ Show the Full List of 8 Patented Agent(s)
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine DMARZHU Discovery agent N.A. Investigative [3]

References

1 FAP inhibitors. US9346814.
2 Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836.
3 Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006 Jun 28;72(1):70-9.
4 Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides. J Neurochem. 1989 Apr;52(4):1284-93.