Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEM6GYO)

DME Name	Beta-glucosidase (bglA)
Synonyms	Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; DCY19_10210
Gene Name	DCY19_10210
UniProt ID	A0A351PC96_9FIRM
INTEDE ID	DME1147
EC Number	EC: 3.2.1.21 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Eubacterium cellulosolvens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Eubacteriaceae Genus: Eubacterium Species: Eubacterium cellulosolvens
Tissue Distribution	Primarily distributed in human gut.
Sequence	MFRDDFVWGVASSAYQVEGTDPEDGRGKCVWDVFTEEGHIHENQNAYTACDHMHRYKEDY ALMRQLGIKAYRFSMNWARILPEGTGRVNEKAIAMYRDMIVTMKENGITPYITMFHWELP QALQVKGGWLNPQIVDWFGEYARVIAENFADLCDYFITINEPQCVVGLGHLSAVHAPGVR HTVTDTFQIAHNLLKAHGQAVINLRKYAGRPIKVGYAPTGGVAYPYTDSPEDIEAARKVY FGFYNPLDNWTWNVAWFSDPVFLGHYPEEGLKKFKKYLPDITKEDMELIHQPLDFMGQNI YNGYFVRAGKDGEPEFVDRAPGFPRTAAGWPVTPRAFYYGIKFLYERYKLPLYITENGMS CHDLVSSDHKVHDPNRITFLESYIKGMEKAIDEGADVRGYFEWTFLDNFEWADGYTQRFG MVYVDFTTQERIPKDSAYWYSKVIESNGRCLPETGILWC
Function	This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[1], [2]
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1 Preclinical Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[2]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1], [2]
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References

1	Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998 Oct;50(10):1155-60.
2	Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.