Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEMEPVJ)
| DME Name | Acyl-CoA thioesterase 2 (ACOT2) | ||||
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| Synonyms | Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2, mitochondrial; CTE-Ia; Long-chain acyl-CoA thioesterase 2; ACOT2; PTE2; PTE2A; ZAP128 | ||||
| Gene Name | ACOT2 | ||||
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| 3D Structure | |||||
| Gene ID | |||||
| EC Number | EC: 3.1.2.2 | ||||
| Lineage | Species: Homo sapiens | ||||
| Sequence |
MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVP
ARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLG ELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGR LLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLL AGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELC LSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNS PLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPET GHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIP SKV |
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| Function |
This enzyme catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. It displays higher activity toward long chain acyl CoAs (C14-C20). And it is involved in enhancing the hepatic fatty acid oxidation in mitochondria.
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Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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