Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEMI4VE)

DME Name Carboxylesterase 3 (CES3)
Synonyms Liver carboxylesterase 3; Liver carboxylesterase 31 homolog; CES3; UNQ869/PRO1887
Gene Name CES3
UniProt ID
EST3_HUMAN
INTEDE ID
DME0056
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
23491
EC Number EC: 3.1.1.1
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVF
LGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSV
SEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRL
GVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVL
SPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEE
LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLD
TMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINV
PTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRL
AFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFR
EAWMQFWSETLPSKIQQWHQKQKNRKAQEDL
Function
This enzyme is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. It shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Reactome Pathway
Phase I - Functionalization of compounds (R-HSA-211945 )
LDL clearance (R-HSA-8964038 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [1]
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrethroids DM1794O Pest attack N.A. Phase 2 [2]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.85E-02 8.21E-02 3.58E-01
Alopecia ED70 Skin from scalp 3.46E-01 9.57E-02 2.85E-01
Alzheimer's disease 8A20 Entorhinal cortex 6.24E-04 -5.07E-02 -3.12E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.64E-01 5.82E-02 4.85E-01
Aortic stenosis BB70 Calcified aortic valve 4.55E-01 1.66E-01 5.57E-01
Apnea 7A40 Hyperplastic tonsil 8.42E-01 -6.04E-02 -2.71E-01
Arthropathy FA00-FA5Z Peripheral blood 2.80E-01 2.75E-02 2.77E-01
Asthma CA23 Nasal and bronchial airway 1.54E-02 5.24E-02 8.22E-02
Atopic dermatitis EA80 Skin 9.41E-04 1.24E-01 9.04E-01
Autism 6A02 Whole blood 7.92E-01 9.98E-02 3.69E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.57E-01 -1.31E-01 -9.68E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.68E-01 2.18E-02 1.81E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.17E-01 9.37E-02 3.38E-01
Batten disease 5C56.1 Whole blood 4.24E-01 -2.57E-03 -3.98E-02
Behcet's disease 4A62 Peripheral blood 5.13E-01 -6.05E-02 -1.99E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 4.13E-01 -5.31E-02 -2.99E-01
Bladder cancer 2C94 Bladder tissue 6.50E-04 3.69E-01 1.89E+00
Breast cancer 2C60-2C6Z Breast tissue 3.87E-07 -1.60E-01 -4.95E-01
Cardioembolic stroke 8B11.20 Whole blood 2.28E-01 3.61E-02 2.20E-01
Cervical cancer 2C77 Cervical tissue 1.99E-05 -2.53E-01 -1.37E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 5.59E-01 3.63E-02 1.42E-01
Chronic hepatitis C 1E51.1 Whole blood 1.23E-01 3.64E-02 1.82E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.28E-01 3.03E-02 1.52E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.60E-01 -5.43E-02 -2.04E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 7.73E-01 6.72E-02 2.04E-01
Colon cancer 2B90 Colon tissue 2.70E-117 -1.42E+00 -3.83E+00
Coronary artery disease BA80-BA8Z Peripheral blood 5.21E-01 -5.28E-02 -1.09E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 5.85E-01 -2.16E-01 -8.14E-01
Endometriosis GA10 Endometrium tissue 3.60E-02 -9.23E-02 -3.37E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 6.41E-01 -5.91E-02 -3.14E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.52E-05 -2.87E-01 -1.01E+00
Gastric cancer 2B72 Gastric tissue 8.28E-01 1.77E-01 3.36E-01
Glioblastopma 2A00.00 Nervous tissue 1.20E-01 1.42E-02 5.35E-02
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 6.08E-01 1.58E-01 5.63E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 6.23E-01 -1.38E-01 -4.25E-01
Head and neck cancer 2D42 Head and neck tissue 5.29E-08 -1.93E-01 -7.21E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.30E-01 -5.25E-02 -4.14E-01
Huntington's disease 8A01.10 Whole blood 6.39E-01 8.18E-02 6.27E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.12E-01 7.93E-02 3.83E-01
Immunodeficiency 4A00-4A20 Peripheral blood 2.06E-01 6.07E-02 5.89E-01
Influenza 1E30 Whole blood 1.44E-02 2.81E-01 1.93E+00
Interstitial cystitis GC00.3 Bladder tissue 8.69E-01 9.86E-03 1.71E-01
Intracranial aneurysm 8B01.0 Intracranial artery 4.49E-01 -9.19E-02 -3.08E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.45E-02 3.92E-02 6.81E-02
Ischemic stroke 8B11 Peripheral blood 1.34E-01 9.69E-02 6.03E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 3.44E-06 1.74E-01 6.97E-01
Lateral sclerosis 8B60.4 Skin 6.52E-01 -2.01E-02 -1.13E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 2.65E-01 1.46E-01 4.38E-01
Liver cancer 2C12.0 Liver tissue 2.09E-09 -6.71E-01 -1.47E+00
Liver failure DB99.7-DB99.8 Liver tissue 2.60E-02 -1.64E-01 -5.07E-01
Lung cancer 2C25 Lung tissue 1.56E-14 1.28E-01 5.38E-01
Lupus erythematosus 4A40 Whole blood 4.55E-01 -3.84E-02 -5.14E-02
Major depressive disorder 6A70-6A7Z Hippocampus 2.74E-01 7.13E-02 4.17E-01
Major depressive disorder 6A70-6A7Z Whole blood 5.15E-01 -1.63E-02 -8.01E-02
Melanoma 2C30 Skin 2.02E-01 -2.91E-02 -6.63E-02
Multiple myeloma 2A83.1 Peripheral blood 5.41E-01 -3.64E-02 -1.53E-01
Multiple myeloma 2A83.1 Bone marrow 1.01E-01 1.22E-01 5.05E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 6.75E-01 -9.11E-02 -4.48E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.84E-01 -2.08E-02 -1.52E-01
Myelofibrosis 2A20.2 Whole blood 8.13E-01 6.15E-02 4.93E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.66E-01 2.62E-01 4.15E-01
Myopathy 8C70.6 Muscle tissue 1.62E-02 -1.46E-01 -8.00E-01
Neonatal sepsis KA60 Whole blood 2.06E-04 -1.42E-01 -5.39E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.78E-02 -3.78E-01 -9.71E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 2.31E-01 3.55E-01 1.04E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.74E-01 9.66E-02 5.38E-01
Olive pollen allergy CA08.00 Peripheral blood 7.25E-01 -3.15E-02 -1.23E-01
Oral cancer 2B6E Oral tissue 9.38E-01 -6.44E-02 -2.50E-01
Osteoarthritis FA00-FA0Z Synovial tissue 4.01E-01 -2.38E-01 -6.37E-01
Osteoporosis FB83.1 Bone marrow 5.71E-01 1.89E-01 8.65E-01
Ovarian cancer 2C73 Ovarian tissue 1.01E-01 5.74E-02 3.63E-01
Pancreatic cancer 2C10 Pancreas 9.75E-04 -4.17E-01 -1.43E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 7.16E-01 -7.10E-03 -5.68E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.61E-01 -2.36E-03 -1.43E-02
Pituitary cancer 2D12 Pituitary tissue 1.94E-01 1.13E-01 2.84E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.18E-01 1.59E-01 4.30E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.88E-01 -4.02E-03 -2.56E-02
Polycythemia vera 2A20.4 Whole blood 4.16E-01 -2.57E-02 -1.87E-01
Pompe disease 5C51.3 Biceps muscle 4.01E-01 -6.24E-02 -3.50E-01
Preterm birth KA21.4Z Myometrium 8.90E-01 0.00E+00 0.00E+00
Prostate cancer 2C82 Prostate 4.62E-04 -8.91E-01 -1.25E+00
Psoriasis EA90 Skin 3.06E-01 -6.20E-02 -1.71E-01
Rectal cancer 2B92 Rectal colon tissue 8.54E-07 -1.22E+00 -5.12E+00
Renal cancer 2C90-2C91 Kidney 2.43E-02 9.88E-02 3.23E-01
Retinoblastoma 2D02.2 Uvea 8.62E-02 -1.10E-01 -5.79E-01
Rheumatoid arthritis FA20 Synovial tissue 1.19E-01 2.48E-01 1.06E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.27E-01 -1.85E-02 -1.24E-01
Schizophrenia 6A20 Prefrontal cortex 3.16E-01 4.42E-04 2.04E-03
Schizophrenia 6A20 Superior temporal cortex 2.98E-01 -7.93E-03 -8.31E-02
Scleroderma 4A42.Z Whole blood 7.09E-04 5.13E-01 1.96E+00
Seizure 8A60-8A6Z Whole blood 3.63E-01 -1.23E-01 -6.04E-01
Sensitive skin EK0Z Skin 5.68E-01 -8.63E-03 -4.68E-02
Sepsis with septic shock 1G41 Whole blood 4.48E-01 -3.23E-03 -1.15E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 6.48E-01 5.85E-02 2.48E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.30E-01 3.08E-01 1.26E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 3.38E-01 1.42E-01 8.76E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.98E-01 -3.31E-01 -1.47E+00
Skin cancer 2C30-2C3Z Skin 5.52E-02 1.29E-02 3.25E-02
Thrombocythemia 3B63 Whole blood 6.11E-01 2.50E-02 1.75E-01
Thrombocytopenia 3B64 Whole blood 7.80E-01 4.49E-02 1.93E-01
Thyroid cancer 2D10 Thyroid 1.83E-04 1.37E-01 5.50E-01
Tibial muscular dystrophy 8C75 Muscle tissue 4.69E-07 -4.63E-01 -2.39E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 7.36E-02 1.72E-01 2.45E+00
Type 2 diabetes 5A11 Liver tissue 3.68E-01 -1.09E-01 -4.42E-01
Ureter cancer 2C92 Urothelium 5.87E-01 -1.44E-01 -5.30E-01
Uterine cancer 2C78 Endometrium tissue 4.56E-05 -1.92E-01 -5.35E-01
Vitiligo ED63.0 Skin 8.92E-01 1.72E-03 1.07E-02
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
2 Pyrethroids: mammalian metabolism and toxicity. J Agric Food Chem. 2011 Apr 13;59(7):2786-91.