Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEMSNER)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; blaC
Gene Name	blaC
UniProt ID	A4LA84_EDWTA
INTEDE ID	DME1033
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Edwardsiella tarda Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Hafniaceae Genus: Edwardsiella Species: Edwardsiella tarda
Tissue Distribution	Primarily distributed in human gut.
Sequence	MMNTRLSCTLALSALLLSSGAQASTPPSAEMRVAEAVKQTIPALMQQQQIPGMAVAVIYQ GTPYYFSYGVADKATRRAVTPQTLFELGSVSKTFTGVLGGYALQRGDIRLQDTVASQWPA LNGPQWRAITLQQLATYTAGGLPLQVPDAVTDTAQLLDFYQRWQPRWAPGTMRSYSNASI GLFGMLAVRPSGMDFSQAMTRWVLQPLGLKHTYFRVPPAAEGEYAWGYREGKALRVSPGM LEQEAYGIKSSAQDMATWLQANLDPAAVTQATLRQALLRAQTRYYQSGEMYQGLGWEMLS WPLQAQTLIDGSDNRVALQPQPVHLIEPPTPPQPASWVHKTGSTNGFGAYIAFIPGSRLG IVMLANKNYPNPARVQAAYTILQQLQ
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[1]
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References

1	Comparison of antimicrobial susceptibility, beta-lactamase production, plasmid analysis and serum bactericidal activity in Edwardsiella tarda, E. ictaluri and E. hoshinae. J Med Microbiol. 1993 Oct;39(4):273-81.