Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEMZ1HA)

DME Name	Xylose isomerase (xylA)
Synonyms	Xylose isomerase xylA; Isomerase xylA; Enzyme xylA; xylA; DEB64_01060
Gene Name	xylA
UniProt ID	A0A358M0K8_9BACT
INTEDE ID	DME1694
EC Number	EC: 5.3.1.5 Isomerase Intramolecular oxidoreductase Aldose/ketose isomerase EC: 5.3.1.5
Lineage	Species: Alistipes indistinctus Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Rikenellaceae Genus: Alistipes Species: Alistipes indistinctus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MAKQYFPTVGKIAFEGTSSKNPMAFRYYEPERVVKGRKMKDWLRFSMAWWHTLCAEGADQ FGGGTKQFAWNEAACPIERAKAKMDAGFEFMQKMGIEYYCFHDVDLVDEDPDPVKYEQNL REIVAYAKQKQAETGIKLLWGTANVFGNARYMNGASTNPDFDTAARAMLQIKNAIDATIE LGGENYVFWGGREGYMSLLNTDMKREKEHMATMLTMARDYARSKGFKGNFLIEPKPMEPM KHQYDVDTETVIGFLRAHGLDKDFKVNIEVNHATLAGHTFEHELQCAVDAGMLGSIDANR GDYQNGWDTDQFPIDLYEMVQAMMVIVRGGGLQGGGTNFDAKTRRNSTDPEDLFIAHIAA MDVMARALLIAADLLDNSPYQKMLAERYASYDKGEGKAFEEGKLTLEQVADYARTHEPVQ HSGKQELYEAILNMYM
Function	This enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. It binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Xylose	DMAR467	Gastrointestinal disease	DE2Z	Approved	[1]
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References

1	Bacterial xylose isomerases from the mammal gut Bacteroidetes cluster function in Saccharomyces cerevisiae for effective xylose fermentation. Microb Cell Fact. 2015 May 17;14:70.