Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEOHI3U)

DME Name	Beta-glucosidase (bglA)
Synonyms	Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Btheta7330_04370; ERS852511_03465; SAMN02910322_04182; bglX_4; bglX_8
Gene Name	bglX_4
UniProt ID	A0A0P0FEZ9_BACT4
INTEDE ID	DME1842
EC Number	EC: 3.2.1.21 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Bacteroides thetaiotaomicron Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides thetaiotaomicron
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKVIKIFSACLFLLPFVSCTQVTNDKGDTAIEKKVEALLSKMTLEEKLGQMNQITSYGNI EDMSGLIKQGGAGSILNETDPVRINALQRVAIEESRLSIPLLMARDVIHGFKTIFPIPLG QAASFNPQVAEDGARVAAIEASSVGIRWTFAPMIDIARDPRWGRMAEGCGEDTYLTTVMG VAMVKGFQGDSLNSPTSIASCPKHFVGYGAAEGGRDYNSTFIPERRLRNVYLPPFEAASK AGAATFMTSFNDNDGVPSTGNSFILKDVLRSEWGFDGLVVTDWASSTEMIAHGFAADSKE VAMKAVNAGVDMEMVGNTFVKELPGLIKEGKVKEAEIDNAVRNILRIKYRLGLFENPYVD EKANVLYAPSHLEAAKQAATESAILLKNDHETLPLQSSVKTIAIVGPMANAPYDQLGTWV FDGEKSHTMTPLTAIKELADDKVQIIYEPGLTYSRDKNIAGVAKAAAAAARADVILAFVG EEAILSGEAHCLADLNLQGAQSELISALAKTGKPVVTIVMAGRPLTIGKETELSSALLYS FHPGTMGGPALADLLFGKAVPSGKTPVTFPKMVGQVPVYYAHNNTGRPATRSEVLIDDIA LEAGQTSLGCTSFYMDAGFDPLFPFGYGLSYTTFQYGNVKLSSDNLKKDDVLTVTFDLEN TGKYEGTEVAQLYVQDMIGSVTRPVKELKRFTRVTLKPGEKKTVSFELPISELAFWNIDM VKTVEPGDFALWVAPDSQSGEKNLFKVVD
Function	This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
KEGG Pathway	Biosynthesis of secondary metabolites (btho01110 ) Cyanoamino acid metabolism (btho00460 ) Metabolic pathways (btho01100 ) Starch and sucrose metabolism (btho00500 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DB-041901	DM7JV4O	N. A.	N. A.	Phase 2	[1]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[2]
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References

1	Gut microbiota-mediated drug-antibiotic interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9.
2	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.