Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEOWDK1)

DME Name	Oxygen-insensitive NADPH nitroreductase B (nfsB)
Synonyms	Oxygen-insensitive NAD(P)H nitroreductase B; Dihydropteridine reductase; FMN-dependent nitroreductase; STM0578; pnrB
Gene Name	nfsB
UniProt ID	NFSB_SALTY
INTEDE ID	DME1617
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	1252098
EC Number	EC: 1.5.1.34 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.34
Lineage	Species: Salmonella enterica Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Salmonella Species: Salmonella enterica Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium TA100
Tissue Distribution	Primarily distributed in human gut.
Sequence	MDIVSVALQRYSTKAFDPSKKLTAEEADKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV AKSAAGNYTFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEDADGRFATPEAKAANDKG RRFFADMHRVSLKDDHQWMAKQVYLNVGNFLLGVAAMGLDAVPIEGFDAEVLDAEFGLKE KGYTSLVVVPVGHHSVEDFNAGLPKSRLPLETTLTEV
Function	This enzyme can reduce a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. And it also can reduce nitrofurazone.
KEGG Pathway	( ) ( )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	Trypanosomiasis	1D51-1F53	Phase 1	[1]
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3 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[2]
CL-205086	DMB6XUY	Intestinal amebiasis	1A36	Investigative	[1]
Nitroimidazole	DMMY2S5	Trypanosomiasis	1D51-1F53	Investigative	[1]
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References

1	Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8.
2	Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012 Apr 15;197(1):16-22.