Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEP0IWS)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; bla_2; NCTC5046_06338
Gene Name	bla_2
UniProt ID	A0A378EHS6_KLEPR
INTEDE ID	DME1023
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Klebsiella pneumoniae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Tissue Distribution	Primarily distributed in human lung.
Sequence	MVMRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGEL CAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPRRRPATPL PRPAWPRPCASC
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

6 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[1]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[1]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[1]
Levofloxacin	DMS60RB	Acute maxillary sinusitis		Approved	[1]
Cotrimoxazole	DMSW5QP	N. A.	N. A.	Phase 4	[1]
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⏷ Show the Full List of 6 Approved Drug(s)

References

1	Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.