Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEP7ECA)

DME Name	Nitroreductase (NTR)
Synonyms	FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; AC1_0194
Gene Name	NTR
UniProt ID	B1R7B9_CLOPF
INTEDE ID	DME1245
Gene ID	29572702
EC Number	EC: 1.5.1.39 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.39
Lineage	Species: Clostridium perfringens Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Clostridium Species: Clostridium perfringens Subspecies: Clostridium perfringens B str. ATCC 3626
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKLDRKDIIDIFNFRFATKEFTGEIIPKEDMEMIAETARLSPSSFGLEPWKFLIVENKEL IKEISEVSWGFQRQASTTSHIVIALTKAGSEVKYDSDYIRNLWINTKGVSEEFFEGIKDV LKNFQVGKLEADETNEKLLEWSKRQTYIALGNMMTAAAMREIDSCAIEGFDKEKVEEILA KKGILDKEKYELTYLIAFGYRKEDPNRKKSRLPKSEVIQWVE
Function	This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metronidazole	DMTIVEN	Abscess		Approved	[1]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[2]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
P-nitrobenzoic acid	DMVJUOZ	N. A.	N. A.	Investigative	[2]
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References

1	Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.
2	Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.