| DME Name |
UDP-glucuronosyltransferase 1A5 (UGT1A5)
|
| Synonyms |
UDP-glucuronosyltransferase family 1 member A5; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1-5; UDPGT 1-5; UGT-1E; UGT1*5; UGT1-05; UGT1.5; UGT1A5; UGT1E |
| Gene Name |
UGT1A5
|
| UniProt ID |
|
| INTEDE ID |
|
| 3D Structure |
|
| Gene ID |
|
| EC Number |
EC: 2.4.1.17
- Transferase
- Glycosyltransferases
- Hexosyltransferase
- EC: 2.4.1.17
|
| Lineage |
Species: Homo sapiens
- Kingdom: Metazoa
- Phylum: Chordata
- Class: Mammalia
- Order: Primates
- Family: Hominidae
- Genus: Homo
- Species: Homo sapiens
|
| Sequence |
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
|
| Function |
This enzyme is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. And the isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
|
| KEGG Pathway |
- Ascorbate and aldarate metabolism (hsa00053 )
- Chemical carcinogenesis (hsa05204 )
- Drug metabolism - cytochrome P450 (hsa00982 )
- Drug metabolism - other enzymes (hsa00983 )
- Metabolic pathways (hsa01100 )
- Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
- Pentose and glucuronate interconversions (hsa00040 )
- Porphyrin and chlorophyll metabolism (hsa00860 )
- Retinol metabolism (hsa00830 )
- Steroid hormone biosynthesis (hsa00140 )
|
| Reactome Pathway |
- Glucuronidation (R-HSA-156588 )
|
|
|
|
|
|
|
