Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQ1CTE)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; C7120_10955
Gene Name	C7120_10955
UniProt ID	A0A2T4TNV5_9BACT
INTEDE ID	DME1921
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Prevotella copri Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Prevotellaceae Genus: Prevotella Species: Prevotella copri
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MKLKRLVFLIPIWLIALCSFGQAGHVSARLTLDGKMQALAERLLEGKQGSIVAIEPSTGE VKCLVSKSFLSDTINRAIGQAYSPGSTFKVAQALALVSEGIVNKDSKFTCSEGFWKNNMH IGCHKHSSPQDLIGAIAHSCNSWFCKAFMNMIRDRVKYKNKLEAINKWKEYMSSLGLGRP LGIDMEGETDGEMPDSEMLERLYSGRWNEATIMWVGMGQGEVLATPLQLCNLAAIIANKG YYYIPHIHKDVDTTYTTRRLSTASPEAFELIRKGMRKAVTTGTATAIQHPDWQICGKTGT AENPGEDHSVFIGYAPMNNPKIAVSVYVENAGFGADLAAPLAQLMIEQYLTGKLSERSER KARQWYDFLVVPHDPTEVTEKETPTKIPMPTQPASPSTSPKGKS
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets. Oral Microbiol Immunol. 2002 Apr;17(2):85-8.