Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQLVCA)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase domain protein; GCWU000325_00085
Gene Name	blaB
UniProt ID	C9LD75_9BACT
INTEDE ID	DME1309
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Alloprevotella tannerae Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Prevotellaceae Genus: Alloprevotella Species: Alloprevotella tannerae
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MLKIKRFIFNMVQENCYVLHDETQEGVIIDCGALMPEEEEALRDYIAAEGIQVKHLLHTH SHFDHVFGDQFVYSTYGIKPEMHELEVALYGDVSGQVAMFLHRNISVVVPPLGNVFTGRD EIKFGNHTLEIIETPGHSPGGVCFYCRAEKALFSGDSLFKHEIGRFDFPYGDGAALIDNL KTKILTLPADVNVYPGHGDATSIEEERAYNPYLR
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204.