Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQX0DG)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; FN1584
Gene Name	blaB
UniProt ID	Q8RIK5_FUSNN
INTEDE ID	DME1224
Gene ID	992812
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Fusobacterium nucleatum Kingdom: Bacteria Phylum: Fusobacteria Class: Fusobacteriia Order: Fusobacteriales Family: Fusobacteriaceae Genus: Fusobacterium Species: Fusobacterium nucleatum
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MEKYTEWKKEIEKIISQVDGKICINFYDLDKKNGFSINGNEKVLSASMIKLLILAELMKK VSENKFSLSDTITITNFMKTGGDGVLKELNAGHHFTLKELATLMIIVSDNQATNILIDFL GMENINFLGKELGLRETFLERRMMDAEASKNGYDNYTSADDISLLLKLIYQEKLINKETS QLMLDILLRQQQGERLQRYLPPDIKIAHKCGDLDNLENDGGIIWLGNKIYILVVLTSGMS NLQCRQTIGKISKFVYDKMEESLE
Function	This enzyme hydrolyzes beta-lactam.
KEGG Pathway	beta-Lactam resistance (fnu01501 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
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1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[2]
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References

1	Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.
2	beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children. Antimicrob Agents Chemother. 1999 May;43(5):1270-3.