Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DERI7LO)

DME Name	AmpC beta-lactamase (ampC)
Synonyms	Beta-lactamase ampC; Bacterial burkholderia beta-lactamase ampC; ampC; BMULJ_05519
Gene Name	ampC
UniProt ID	A0A0H3KQ39_BURM1
INTEDE ID	DME1192
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Burkholderia multivorans Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Burkholderiaceae Genus: Burkholderia Species: Burkholderia multivorans Subspecies: Burkholderia multivorans ATCC 17616
Tissue Distribution	Primarily distributed in human lung.
Sequence	MRITVTRVVATLLVATAAIATTGRAAELTQAHIRQIVTQQVAPAMKQYAIPGVAIGVIVD GKRYVFDYGVMSKDTGKPVTADTLFEIGSVSKTLTATLAADAQEGGELSLSDPVARYVPA LNGKPAGALTLLELGTHTAGGLPQQVPDAIHDDATLIGYFDAWRPASVPGTQRVYSNVGI GTLGWITAKAMKRDFAELMERRLFPALGMTHTYIDVPDARRADYAQGYTTDGTPIRMKPG GLWQPAYGVRTTATDLLRFVQANMGGIDIAPRLQRAIERTHTGYFRAGPLTQDLIWEQYP YPVALPTLLEGNASKMLSDAVPAVALTPPLAPQRNVWINKTGSTNGFSTYVAFVPAKRIG FVMLANRRVPNEVRVEIAYRILASLGGAR
Function	This enzyme hydrolyzes beta-lactam.
KEGG Pathway	( ) ( )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[1]
Cefalotin	DMVYSLE	Bacterial infection	1A00-1C4Z	Approved	[1]
Imipenem	DMI9FBP	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18.