Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DERPJZ6)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; PG2010B_0119
• Gene Name: bglA
• UniProt ID: A0A4Q4LS82_BIFAN
• INTEDE ID: DME1205
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Bifidobacterium animalis
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Bifidobacteriales
  Family: Bifidobacteriaceae
  Genus: Bifidobacterium
  Species: Bifidobacterium animalis
  Subspecies: Bifidobacterium animalis subsp. lactis Bi-07
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTMTFPKGFQFGTATAAYQIEGAVDEDGRTPSIWDVFSHTPGRVLNGDTGDKADDFYHRW
  QDDLKLVRDLGVNAYRFSIGVPRVIPTPDGKPNEKGLDFYERIVDQLLEYGIDPIVTLYH
  WDLPQYLNEDPYRGGWLNREIAFRMAEYAGIVAKRLGDRVHTYTTLNEPWCSAHLSYGGT
  EHAPGLGAGPLAFRAAHHLNLAHGLMCEAVRAEAGAKPDLSVTLNLQVNRGDADAVHRVD
  LIANRVFLDPMLRGYYPDELFAITKGICDWDFVHDGDLKLINQPIDVLGLNYYSTNLLAM
  SDRPQFPQSTEASVAPGASDIDWLPTDGPHTQMGWNIDPDALYNTLVRLNDDYDHIPLVV
  TENGMACPDEVEVGPDGVKMVHDDDRIDYLRRHLEAVHRAIEEGANVIGYFVWSLMDNFE
  WAFGYDRRFGLTYVDYDTEERIRKDSYNWYRNFIAEHSAR
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Preclinical Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[1]

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[1]

References

• [1] Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.