Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESHI6O)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; per1; bla; AA416_02797; DHV19_16385
Gene Name	per1
UniProt ID	A0A108T9G3_9BACE
INTEDE ID	DME1348
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Bacteroides cellulosilyticus Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides cellulosilyticus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKAKFFLSCMALAILFSACNTANRTPKQKIEQQIDSLLKDKKATVGVAVLANDETVAVYN NQIHFPLLSVFKFHVGLAVLDKMDKGHIALDSLIEVKSSQLKSNTYSPLRDKFPDQDITI SLGELLKYSISQSDNNACDILIEYAGGIDQVNEYVKSLGIKDCNLAATEDLMHTSGDAYL NWSTPEEVVRLLNIADKQPLFGTQYKDFLQAIMQETSTGKDKLKGQLPADVIVGHKTGSS DRTPEGIKIADNDAGFVILPNGQKYYIAVFVMESQETDTDNAAIIASISKIVYDTLNSDI Q
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.