Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESIWFO)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase; EBR-1
• Gene Name: EBR-1
• UniProt ID: Q8GQK7_9FLAO
• INTEDE ID: DME1222
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Empedobacter brevis
  Kingdom: Bacteria
  Phylum: Bacteroidetes
  Class: Flavobacteriia
  Order: Flavobacteriales
  Family: Flavobacteriaceae
  Genus: Empedobacter
  Species: Empedobacter brevis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKKLFSLIALIGSFAFGQIKPIQIDPINNNLFVYQTFNSFNGVEYNANGMYLVTNKGIVL
  FDVPWQKSQYQELNDMLQEKYNLPVIAVFATHSHDDRAGDLSFYNELNIPTYATSLTNSK
  LKKEGKATSKFEIELGKTYKFGNEKFVFEYFGEGHTSDNVVVWFPKYKVLNGGCLIKGAD
  AVNLGYTGEANVVEWPKTVHKLVAKHPTIKQVIPGHDNWKATGHIENTFKLLEKK
• Function: This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[1]
Carbapenem	DMXZU73	Cystitis	GC00	Phase 4	[1]

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[1]

References

• [1] EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7.