Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DETHCPD)

DME Name Carboxylesterase 2 (CES2)
Synonyms Cocaine esterase; Methylumbelliferyl-acetate deacetylase 2; hCE-2; CE-2; CES2; ICE
Gene Name CES2
UniProt ID
EST2_HUMAN
INTEDE ID
DME0057
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
8824
EC Number EC: 3.1.1.1
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLG
IPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMS
EDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG
VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS
PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI
LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQ
KEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA
LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEE
EQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKK
ALPQKIQELEEPEERHTEL
Function
This enzyme is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. It shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. It also hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol.
KEGG Pathway
Drug metabolism - other enzymes (hsa00983 )
Reactome Pathway
Phase I - Functionalization of compounds (R-HSA-211945 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
3 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [2]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [3]
2 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dabigatran etexilate DMRDZ4X Venous thromboembolism BD72 Phase 3 [4]
Pradaxa DM2ZYX9 Stroke 8B20 Phase 3 [5]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.19E-04 9.06E-02 1.98E-01
Alopecia ED70 Skin from scalp 7.58E-04 -1.42E-01 -5.26E-01
Alzheimer's disease 8A20 Entorhinal cortex 7.74E-08 -1.49E-01 -6.18E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 9.95E-01 -4.01E-02 -2.98E-01
Aortic stenosis BB70 Calcified aortic valve 6.60E-01 -8.37E-02 -4.27E-01
Apnea 7A40 Hyperplastic tonsil 8.50E-01 9.19E-01 4.44E+00
Arthropathy FA00-FA5Z Peripheral blood 1.89E-01 -1.53E-01 -5.75E-01
Asthma CA23 Nasal and bronchial airway 7.27E-03 1.41E-01 2.30E-01
Atopic dermatitis EA80 Skin 1.83E-10 3.81E-01 2.12E+00
Autism 6A02 Whole blood 3.96E-01 -8.22E-02 -2.60E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.48E-01 -3.35E-01 -1.38E+00
Autosomal dominant monocytopenia 4B04 Whole blood 9.94E-01 -2.35E-01 -7.78E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.00E-10 -5.14E-01 -1.20E+00
Batten disease 5C56.1 Whole blood 1.22E-01 -1.69E-01 -2.46E+00
Behcet's disease 4A62 Peripheral blood 4.00E-01 -2.06E-01 -7.83E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.89E-01 -2.65E-02 -1.25E-01
Bladder cancer 2C94 Bladder tissue 1.20E-02 -4.01E-01 -1.59E+00
Breast cancer 2C60-2C6Z Breast tissue 6.74E-36 -3.31E-01 -9.69E-01
Cardioembolic stroke 8B11.20 Whole blood 1.92E-02 -1.45E-01 -7.40E-01
Cervical cancer 2C77 Cervical tissue 1.54E-02 -4.22E-01 -9.48E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.66E-01 5.10E-02 1.88E-01
Chronic hepatitis C 1E51.1 Whole blood 1.25E-01 -1.52E-01 -1.09E+00
Chronic obstructive pulmonary disease CA22 Lung tissue 1.06E-02 -2.34E-01 -8.30E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.79E-03 1.30E-01 4.68E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 5.28E-01 -2.23E-01 -6.98E-01
Colon cancer 2B90 Colon tissue 3.74E-176 -2.12E+00 -5.16E+00
Coronary artery disease BA80-BA8Z Peripheral blood 4.36E-01 6.66E-01 8.17E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 4.53E-01 6.58E-02 1.66E-01
Endometriosis GA10 Endometrium tissue 7.54E-01 1.57E-01 3.16E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.25E-01 2.64E-02 2.15E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.23E-12 9.14E-01 2.57E+00
Gastric cancer 2B72 Gastric tissue 7.08E-03 5.98E-01 3.42E+00
Glioblastopma 2A00.00 Nervous tissue 8.60E-02 -6.91E-02 -2.24E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 2.50E-01 -4.10E-01 -1.50E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.46E-01 1.42E-01 4.02E-01
Head and neck cancer 2D42 Head and neck tissue 1.42E-08 -3.33E-01 -3.55E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.69E-02 1.51E-01 5.18E-01
Huntington's disease 8A01.10 Whole blood 8.95E-01 1.31E-01 8.01E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.80E-03 6.63E-01 2.65E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.83E-01 1.39E-01 6.47E-01
Influenza 1E30 Whole blood 1.32E-01 -2.69E-01 -1.35E+00
Interstitial cystitis GC00.3 Bladder tissue 7.78E-03 -4.19E-01 -2.34E+00
Intracranial aneurysm 8B01.0 Intracranial artery 7.42E-01 4.40E-02 1.12E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.41E-02 -4.32E-01 -8.12E-01
Ischemic stroke 8B11 Peripheral blood 1.13E-02 -2.97E-01 -1.28E+00
Juvenile idiopathic arthritis FA24 Peripheral blood 7.55E-06 -2.26E-01 -6.48E-01
Lateral sclerosis 8B60.4 Skin 1.99E-01 -2.62E-01 -1.29E+00
Lateral sclerosis 8B60.4 Cervical spinal cord 9.40E-02 8.26E-01 1.53E+00
Liver cancer 2C12.0 Liver tissue 1.23E-08 -5.09E-01 -9.37E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.95E-02 -1.16E+00 -2.98E+00
Lung cancer 2C25 Lung tissue 5.70E-09 -2.45E-01 -8.70E-01
Lupus erythematosus 4A40 Whole blood 5.27E-01 -3.53E-03 -1.64E-02
Major depressive disorder 6A70-6A7Z Hippocampus 1.34E-01 -5.35E-02 -2.63E-01
Major depressive disorder 6A70-6A7Z Whole blood 9.46E-01 -6.36E-02 -2.19E-01
Melanoma 2C30 Skin 6.70E-01 -3.75E-01 -4.12E-01
Multiple myeloma 2A83.1 Peripheral blood 3.54E-01 -4.48E-02 -2.54E-01
Multiple myeloma 2A83.1 Bone marrow 1.88E-02 2.26E-01 1.36E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.63E-02 1.29E-01 5.47E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 4.12E-01 3.84E-02 1.46E-01
Myelofibrosis 2A20.2 Whole blood 1.25E-01 -7.59E-02 -5.00E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.35E-01 -1.63E-02 -3.27E-02
Myopathy 8C70.6 Muscle tissue 7.66E-02 5.12E-01 8.87E-01
Neonatal sepsis KA60 Whole blood 1.02E-03 1.77E-01 4.82E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.38E-02 -9.81E-02 -9.56E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 2.02E-02 -4.39E-01 -1.44E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.70E-01 2.78E-01 7.29E-01
Olive pollen allergy CA08.00 Peripheral blood 4.94E-01 1.37E-01 3.19E-01
Oral cancer 2B6E Oral tissue 2.20E-03 -6.02E-01 -5.34E-01
Osteoarthritis FA00-FA0Z Synovial tissue 2.30E-01 4.90E-01 9.30E-01
Osteoporosis FB83.1 Bone marrow 1.81E-01 2.36E-01 1.34E+00
Ovarian cancer 2C73 Ovarian tissue 6.46E-03 -4.91E-01 -1.38E+00
Pancreatic cancer 2C10 Pancreas 1.78E-05 4.02E-01 8.77E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 1.23E-02 -2.25E-01 -8.52E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 5.12E-05 4.05E-01 1.74E+00
Pituitary cancer 2D12 Pituitary tissue 3.43E-01 -5.62E-02 -2.45E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.92E-01 1.65E-01 6.89E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 8.41E-01 3.67E-02 2.41E-01
Polycythemia vera 2A20.4 Whole blood 2.75E-07 -2.06E-01 -1.24E+00
Pompe disease 5C51.3 Biceps muscle 1.06E-03 1.30E+00 3.24E+00
Preterm birth KA21.4Z Myometrium 6.93E-01 -1.69E-02 -7.10E-02
Prostate cancer 2C82 Prostate 1.44E-03 -5.93E-01 -9.89E-01
Psoriasis EA90 Skin 3.13E-01 -1.30E-01 -2.97E-01
Rectal cancer 2B92 Rectal colon tissue 5.86E-13 -1.33E+00 -7.36E+00
Renal cancer 2C90-2C91 Kidney 1.92E-01 -1.68E-01 -1.98E-01
Retinoblastoma 2D02.2 Uvea 2.13E-03 -2.84E-01 -1.49E+00
Rheumatoid arthritis FA20 Synovial tissue 6.66E-04 7.49E-01 2.47E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.59E-02 -1.87E-01 -6.45E-01
Schizophrenia 6A20 Prefrontal cortex 7.73E-01 2.92E-02 1.39E-01
Schizophrenia 6A20 Superior temporal cortex 7.44E-01 8.02E-03 3.08E-02
Scleroderma 4A42.Z Whole blood 3.05E-08 -4.06E-01 -3.72E+00
Seizure 8A60-8A6Z Whole blood 4.28E-01 1.40E-01 5.07E-01
Sensitive skin EK0Z Skin 3.52E-01 1.28E-01 7.52E-01
Sepsis with septic shock 1G41 Whole blood 4.35E-01 -1.44E-02 -6.32E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.42E-02 -2.59E-01 -2.39E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.79E-02 -3.96E-01 -1.22E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 1.46E-01 3.06E-01 1.65E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 4.78E-02 5.08E-01 2.35E+00
Skin cancer 2C30-2C3Z Skin 7.68E-29 -5.92E-01 -1.26E+00
Thrombocythemia 3B63 Whole blood 8.89E-03 -1.18E-01 -7.49E-01
Thrombocytopenia 3B64 Whole blood 8.41E-01 9.24E-02 1.09E-01
Thyroid cancer 2D10 Thyroid 2.61E-13 -3.61E-01 -9.01E-01
Tibial muscular dystrophy 8C75 Muscle tissue 3.55E-04 9.25E-01 1.82E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 2.17E-01 1.45E-02 3.90E-01
Type 2 diabetes 5A11 Liver tissue 1.51E-01 -1.75E-01 -7.24E-01
Ureter cancer 2C92 Urothelium 7.50E-01 -4.43E-02 -1.67E-01
Uterine cancer 2C78 Endometrium tissue 9.57E-01 -1.04E-01 -2.24E-01
Vitiligo ED63.0 Skin 4.22E-01 -9.86E-02 -3.55E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84.
2 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
3 Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011 Dec;5(4):280-9.
4 Pharmacogenomics of novel direct oral anticoagulants: newly identified genes and genetic variants. J Pers Med. 2019 Jan 17;9(1). pii: E7.
5 Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704.