Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DETQXR5)

DME Name	Beta-glucosidase (bglA)
Synonyms	Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; TERG_00481
Gene Name	bglA
UniProt ID	F2SBM1_TRIRC
INTEDE ID	DME1047
Gene ID	10373795
EC Number	EC: 3.2.1.21 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Trichophyton rubrum Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Onygenales Family: Arthrodermataceae Genus: Trichophyton Species: Trichophyton rubrum Subspecies: Trichophyton rubrum NCPF 0118
Tissue Distribution	Primarily distributed in human skin.
Sequence	MLFRWCPLVALAIASGTAATESWESPPYYPSPWTKGEGEWEAAYQKAVSFVSQLTLAEKV NLTTGVGWMQESCVGQVGSIPRLGFRSLCMQDGPLGIRFGDYVTAFPAGINVAATWSREL AYLRGKAMGEEFRGKGADVILGPAIGPIGRAPEGGRNWEGLGPDPVLAGKLVAETIKGMQ KSGVIACAKHFIANEQERFRIAAEAQGYGFDIAESISSNVDDVTMHEIYLWPFADAVKAG VGSIMCSYNQINNSYGCGNSYTQNKLLKGELGFRGFIMSDWQAHHSGVGSAFAGLDMSMP GDTLFGTGVSYWGANLTIAVANGTIPEWRVDDMAVRIMAAYYKVGRDQVQVPINFNSWTT DVEGYQHALVKEGYGVVNQRVNVRDHHAQIARRVARDSTVLLKNEGVLPLTGTEQFTAII GEDAGPNINGPNSCPDRGCDNGTLAMGWGSGTTNFPYLVTPDDAIQREIVGKGVGNVMSV LQNGDFKNIQSVAGQADVALVFINSDSGEGYISVDGNEGDRKNLTTWKGGDEMVKQVTSV CNNTVLVIHSSGPILAGEWHDNPNITAILWAGLPGQESGNALVDILYGKENPGGKSPFTW ARTAEDYGTTILREPNNGKGAPQHLFSEGIMFEYRHFDQKNITPVYEFGYGLSYTTFSYS NLKVRPMRANKYVPATGMTKPAPRLGHSSTKYADYLFPGGFKGVTKYVYSWLTSTDPKEA SGDKNYGMPLEDYVPPNANNGDAQPVLPASGVPGGNPGLFEDLYEVSAVITNDGDRVGEE VPQLYISLGGDRNAKVVLRGFDRIRLAPHQRFRWRTTITRRDVSNWDPASQDWVMTENPK IVYVGSSSRNLPLQAPLPAPNLA
Function	This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Esculin	DMANEC9	N. A.	N. A.	Investigative	[1], [2]
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References

1	A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
2	Isolation of transcripts overexpressed in the human pathogen Trichophyton rubrum grown in lipid as carbon source. Can J Microbiol. 2011 Apr;57(4):333-8.