Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEUQTKA)

DME Name	Beta-glucosidase (bglA)
Synonyms	Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BGK71_01895
Gene Name	bglA
UniProt ID	A0A249DCH3_LACRH
INTEDE ID	DME1207
EC Number	EC: 3.2.1.21 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Lactobacillus rhamnosus Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus rhamnosus Subspecies: Lactobacillus rhamnosus HN001 Subspecies: Lactobacillus rhamnosus subsp. Rhamnosus NCTC 10302
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTQQQLYTPKGFPKNFLWGGAIAANQAEGAWQTDGRGPSQADIMLLPEKYSRLGSFGEHV TRADIERALADKSGNYPRRRGIDFFHTYDSDLDLMKEMGFNTFRTSFSWSRIFPNGDEKE PNEKGLKFYDKLIQKMLDLDITPVMTISHYEMPLNLITKYGGWENPEMINFFNRFAQVLL DRYHDKVKYWIVFNQVNDVYGWGEFAGLGILKENQPNEKQAKFQAVHHQFIANAQTVKYG HQIDNDIKIGMMLGLTNVYPASTKPQDVMATYKRWNKDTFFFSDVLARGEYPGYMLRYFE DNNIQLSIDQKELDLIKNNPVDFIAFSYYSSSLISADTPDSLLPNPELEESIWGWSFDPI GFRYGFNVLWDRYHLPLFVAENGLGALDTVEDNKIHDAYRIKYLKAHIKQMKEAIKDGVH IFGYAAWGPIDIVSYSQAEMSKRYGFVYVDLDDKGNGTGKRIRKDSFYWYQKVIESNGDQ I
Function	This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Preclinical Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCG-208408	DMCFEUG	N. A.	N. A.	Preclinical	[1]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[2]
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2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[2]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[2]
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References

1	Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
2	Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.