Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEUZYD1)

DME Name	ATP-dependent 6-phosphofructokinase (pfkA)
Synonyms	Phosphofructokinase; Phosphohexokinase; Phosphohexokinase pfkA; pfkA; ATP-PFK
Gene Name	pfkA
UniProt ID	PFKA_LACDE
INTEDE ID	DME1154
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	4085048
EC Number	EC: 2.7.1.11 Transferase Kinase Phosphotransferase EC: 2.7.1.11
Lineage	Species: Lactobacillus delbrueckii Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus delbrueckii Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKRIGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAGDIFPLESEDVAHL INVSGTFLYSARYPEFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGALQLTRHGFNSI GLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDTASSHHRVFIVNVMGRNCGDIAMRV GVACGADAIVIPERPYDVEEIANRLKQAQESGKDHGLVVVAEGVMTADQFMAELKKYGDF DVRANVLGHMQRGGTPTVSDRVLASKLGSEAVHLLLEGKGGLAVGIENGKVTSHDILDLF DESHRGDYDLLKLNADLSR
Function	This enzyme catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose-6-Phosphate	DMU5SAF	Discovery agent	N.A.	Investigative	[1]
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References

1	Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7.