Details of the Drug

General Information of Drug (ID: DMU5SAF)

Drug Name

Fructose-6-Phosphate

Synonyms

Fructose 6-Phosphate; D-fructose-6-phosphate; fructose-6P; fructose-6-P; D-fructose-6-P; FRUCTOSE -6-PHOSPHATE; fru-6-P; UNII-2012QM764Y; 2012QM764Y; 6814-87-5; keto-D-fructose 6-phosphate; F6R; D-fructose-6P; D-Fructose 6-phosphorate; 6-O-phosphono-D-fructose; Fructose 6-phosphoric acid; SCHEMBL8230; AC1Q28E6; AC1L2C15; CTK5C7413; CHEBI:15946; GSXOAOHZAIYLCY-HSUXUTPPSA-N; Fructose 6-(dihydrogen phosphate); Fructose, 6-(dihydrogen phosphate); EINECS 211-395-6; d-fructose-6-phosphate (open form); ZINC85994845; DB04493; AJ-127870

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 2

Molecular Weight (mw)

260.14

Logarithm of the Partition Coefficient (xlogp)

-4.3

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C6H13O9P
IUPAC Name: [(2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl] dihydrogen phosphate
Canonical SMILES: C([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/t4-,5-,6-/m1/s1
InChIKey: GSXOAOHZAIYLCY-HSUXUTPPSA-N

Cross-matching ID

PubChem CID: 69507
ChEBI ID: CHEBI:15946
CAS Number: 643-13-0
DrugBank ID: DB04493
TTD ID: D0H3IJ
INTEDE ID: DR2145

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fructose-1,6-bisphosphatase (FBP)	TTWHDVK	F16P1_HUMAN ; F16P2_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
ATP-dependent 6-phosphofructokinase (pfkA)_{Main DME}	DEUZYD1	PFKA_LACDE	Substrate	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7.