General Information of Drug-Metabolizing Enzyme (DME) (ID: DEVLXCG)

DME Name Beta-glucosidase (bglA)
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Beta-glucosidase-related glycosidases; BN791_01499
Gene Name BN791_01499
UniProt ID
R7LVY8_9FUSO
INTEDE ID
DME1206
EC Number EC: 3.2.1.21
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage Species: Fusobacterium mortiferum
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium mortiferum
Tissue Distribution Primarily distributed in human gut.
Sequence
MSVTLKEKLYQMFILGTDGGYYKELLKEGLGGIIFFSKDIQTKTQFKSLIDDIKLISKIP
PFLSIDQEGGRVERTENIHNGKKYLSAKFAFEKGEKFLKSQTEEISKELKSYGINLNFAP
CIDTNTNPNNPIIGVRAFSSNPDEVIKAEKIVSKTYEENGIIPCVKHFPGHGDANADSHL
TLPKIDLSLKDMEETHIKPFKSAIENGIDMVMVAHLFCTCFEKEEVPTSLSKNAIDYLRN
NLNFDKVAISDDMVMKGVAKFGDVEACEMGIKAGLNLFIYRFSDEKTSNIIQEIYKKAQK
DNLLKEKIENSYNKIMALKSKYNIA
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
3 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [1]
Glucopyranosyl oleanolate DMRHYU8 N. A. N. A. Investigative [1]
Gypenoside XVII DM8ENQZ N. A. N. A. Investigative [1]

References

1 Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.