General Information of Drug-Metabolizing Enzyme (DME) (ID: DEW6V07)

DME Name Ribosomal 23S RNA methyltransferase Erm (erm)
Synonyms Ribosomal RNA methyltransferase Erm; 23S rRNA methyltransferase Erm; 23S ribosomal RNA methyltransferase Erm; F6I42_04815; erm(X)
Gene Name erm
UniProt ID
A0A5N1AHF6_CORAY
INTEDE ID
DME1156
EC Number EC: 2.1.1.182
Transferase
Methylase
Methyltransferase
EC: 2.1.1.182
Lineage Species: Corynebacterium amycolatum
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium amycolatum
Tissue Distribution Primarily distributed in human skin.
Sequence
MSTYGYGRHEHGQNFLTDHKIINSIVDLVKQTSGPIIEIGPGSGALTHPISRLGRAITAV
EVDAKLAAKLTKKTASASVEVVHDDFLNFPLPATPCVIVGNIPFHLTTAILRKLLHAPAW
TDAVLLMQWEVARRRAGVGASTMMTAQWSPWFTFHLGSRVPRFAFRPQPNVDGGILVIRR
VGDPKIPIEQRKAFQAMVHTVFTARGRGIGEILRRAGLFSSRSETQSWLRSRGIDPATLP
PRLRTSDWIDLFQVTGSSPSHHRPISQSGSSQRPPQRKKRGRRR
Function
This enzyme introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. And Strains lacking the methylase are resistant to kasugamycin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentamycin DM92LH2 Vulvovaginitis GA02.0 Approved [1]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [1]

References

1 High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7.