Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEWYT5M)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; HMPREF0675_4578
Gene Name	blaB
UniProt ID	D4HFC4_CUTAS
INTEDE ID	DME1562
Gene ID	2932324
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Corynebacterium acnes Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Propionibacteriales Family: Propionibacteriaceae Genus: Cutibacterium Species: Corynebacterium acnes
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MTDSVLDVTADALEQAGAHPHRLVVRQHGQVVGRRRWAPWSPDVPSLVYSCSKTFTSAAV GIAVNRGAFGYDDTLADLWPQACTANTGPVAKSMTVRNALSMSTGHSPEQLLEPTLMSRR LPDLNTARILLATEPEGRPGIDFAYNNLATWMLSRLVAQHTGEDVDTIITKEVLDPIGAG PHTWVRDADGIPMGFSGLHIDAEDLSLFGQLLLDDGVHEGARLLPEEWIRQHRVRQVNCD SETDPEWGMGYGWQTWMSSHGYRLDGAFGQYVLIVPEVDAVITMTNEASEGPGDKQAILQ AVWDHLLPALADGFQPQPEEIVRTVPTVTGEFDSARSVQGIAPDGSYIVVSPHKESRTWA MSWRCPGTFSHPTDETLDIAVGYEEWQTSHCRVGDDAIDIATSGGWQGETFVARLCVIST PHTLTLRMTPEATTTEWDNEPLNPGGLLGLVHPELRR
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
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References

1	Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.