Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEX0NP3)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BGK71_01895
• Gene Name: bglA
• UniProt ID: A0A249DCH3_LACRH
• INTEDE ID: DME1043
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Malassezia furfur
  Kingdom: Fungi
  Phylum: Basidiomycota
  Class: Malasseziomycetes
  Order: Malasseziales
  Family: Malasseziaceae
  Genus: Malassezia
  Species: Malassezia furfur
• Tissue Distribution: Primarily distributed in human skin.
• Sequence:
  MTQQQLYTPKGFPKNFLWGGAIAANQAEGAWQTDGRGPSQADIMLLPEKYSRLGSFGEHV
  TRADIERALADKSGNYPRRRGIDFFHTYDSDLDLMKEMGFNTFRTSFSWSRIFPNGDEKE
  PNEKGLKFYDKLIQKMLDLDITPVMTISHYEMPLNLITKYGGWENPEMINFFNRFAQVLL
  DRYHDKVKYWIVFNQVNDVYGWGEFAGLGILKENQPNEKQAKFQAVHHQFIANAQTVKYG
  HQIDNDIKIGMMLGLTNVYPASTKPQDVMATYKRWNKDTFFFSDVLARGEYPGYMLRYFE
  DNNIQLSIDQKELDLIKNNPVDFIAFSYYSSSLISADTPDSLLPNPELEESIWGWSFDPI
  GFRYGFNVLWDRYHLPLFVAENGLGALDTVEDNKIHDAYRIKYLKAHIKQMKEAIKDGVH
  IFGYAAWGPIDIVSYSQAEMSKRYGFVYVDLDDKGNGTGKRIRKDSFYWYQKVIESNGDQ
  I
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Esculin	DMANEC9	N. A.	N. A.	Investigative	[1]

References

• [1] A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.