Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEX7SAW)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; DW927_12715
• Gene Name: bglA
• UniProt ID: A0A3R6A2W5_9FIRM
• INTEDE ID: DME1936
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Roseburia intestinalis
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Roseburia
  Species: Roseburia intestinalis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MFRDDFVWGVASSSYQVEGTDANDGRGKTVWDAFTEAGRIFENQNAYTTCDHMHHYKEDY
  ALMKNLGIKAYRFSLNWARILPEGTGRVNEKAIRMYRDMITCMKENGITPYITMFHWEFP
  QALYEKGGWLNPEVADWFGEYAKVVAERFSDICEYFITINEPQCVVGLGHLSGVHAPGVK
  MSIKDTFQIAHNLMKAHGQAVINLRKYAVRDIKVGYAPTGGVAYPYTDKPEDIEAAKKVY
  FGFYNPMDNWTWNVAWFSDPVFLGHYPKEGLEKFAQYLPEITEEDMKLIHQPLDFMGQNI
  YNGYYVRAGENGEPEFVDREPGFPKTGADWPVTPEAFYYGIKFLTERYPLPLYITENGMS
  CHDNISADGRVHDPNRITFLDSYIGAMQRASDEGADVRGYFLWTFLDNFEWSDGYKQRFG
  IIYVDFTTQQRIVKDSAFWYQKVIETNGGILSMNQANKDILFLDPVCTHNIWGGTKLREE
  FGYPVEGDDIGECWGISAHPNGDGTVRSGAFSGMKLSAVWKEHPEVFGNYDCDRFPLLTK
  IIDARDDLSIQVHPNDDYAKVHENGSFGKTECWYIMDAPEGATLVIGHNAKTKEELSDMI
  HQGRWKEFIREIPVKKGDFIQIDPGTVHAIKGGLLILETQQNSDITYRVYDYDRLSNGKP
  RELHVEKSIDVITVPAKSVDDSVKSALNLPENQLNELYSCKYYTIFKADVNGKMEFEQKY
  PFLLVSVLEGDGIVGSSPVKKGDHFILPNGYGKVEMQGKMSLIVSTVK
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]

References

• [1] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.