Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEX8KJO)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; BACCAP_02761
Gene Name	blaB
UniProt ID	A6NX15_9FIRM
INTEDE ID	DME1013
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Pseudoflavonifractor capillosus Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Pseudoflavonifractor Species: Pseudoflavonifractor capillosus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MYTHSAGGKFLILFSFDSTAGRWDNFFEAQGKSRERMNAAMWKKRLSALALTAVMAVSIS APALAAETEAPATRDESAAMAAQYAAQYGGAVSVQYAVWQDGEITVSGHAGVYSKSENRV LLDTDLYGIGSVSKMYVTAAVMQLVEQGKINLDAPVTKYLPEFKMADERYKDITVRMLLN HSSGLMSATHNMLLFADDDRSATENLLETLSTQRLAADPGAYSTYCNTGFTLAELVVEAV SGKTFPEYLHEAILAPNSLENTFTPQDEFDTSRLVKTYLGEDPRALPQDCLGTVGTGGIY ANAADLAAFGGLLCSDELLTSASLDAMAAPEYSNGIWPDDADDSLAFGLGWDTVSLAPFG YNDIQALAKGGDTQYYHAALVVLPEYDMAAAVLTSGGVSTYNQMAASRMLIDALAEQGVA VDETVPTLPAATPSQTMPAELMDYSGYYASTLQQFKVDISADGVLTLQSLTVPSAPAQTF YYFDDGSFRDQTGTAAMVKPVVEKNGQTYLWQKAYAFLLGLTVLPTSNYVGQKVEPAQLT EDVQAAWDKWNTTSVLPLNEKYSSQVWLSLGSAAVTELPEYIPGYVGAQKIVDANHTQFA VQVPGNAGRDGSDVTVWEEDGHVWMSAQGLLYADASIAQPIYCGAGAYSTVQPDGYARWY TVGSAAGLTIQVEIEGNGGFYVYDGTGSLAASSVVWGDSTVTLPENGVIAFAGDAGARFH ISVVSAE
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	The prevalence of beta-lactamase producing bacteria in subgingival plaque and their sensitivity to Augmentin. Br J Oral Maxillofac Surg. 1990 Jun;28(3):180-4.