Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEXB2A9)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; pse4; NCTC10363_01512
Gene Name	pse4
UniProt ID	A0A379CPC3_PLESH
INTEDE ID	DME1228
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Plesiomonas shigelloides Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Plesiomonas Genus: Plesiomonas Species: Plesiomonas shigelloides
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKVLGRTFFRAAAVVISCWSLAGLAQSSLVKEQDTAALSAQVKSVEQTLGARVGVSVFIP SQGVVWNYHGDQRFPMMSTFKTLACAKMLSDVDAGKLALNDTVKVRSEDLMEYSPVLRPL AGTDITLQAACQATMETSDNTAANLVLEKIGGPAALTAYLQSIGDNVTRLDRNEPTLNEA AKHDPRDTTTPNAINHTLNTLVLGETLSSTSRQQLKTWMQDNKVADGLLRSVLPQGVQIA DRSGAGGFGSRGITALVWSAQQDPMFVSIYLTQTEATFDERNAAIVTIGKSIFDTFLTR
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[1]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[1], [2]
------------------------------------------------------------------------------------

References

1	Beta-lactamase expression in Plesiomonas shigelloides. J Antimicrob Chemother. 2000 Jun;45(6):877-80.
2	Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.