Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEYILK4)

• DME Name: Cytidine deaminase (cdd)
• Synonyms: Cytidine aminohydrolase; Activation-induced cytidine deaminase; Canine hepatic cyd deaminase; AICDA; MHR_0312
• Gene Name: cdd
• UniProt ID: E0TLJ6_MYCHH
• INTEDE ID: DME1196
• EC Number:
  EC: 3.5.4.5
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amidine hydrolase
  EC: 3.5.4.5
• Lineage:
  Species: Mycoplasma hyorhinis
  Kingdom: Bacteria
  Phylum: Tenericutes
  Class: Mollicutes
  Order: Mycoplasmatales
  Family: Mycoplasmataceae
  Genus: Mycoplasma
  Species: Mycoplasma hyorhinis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MFQELEKLLKITYSPYSKFPVAAVIKDAKGNIWKGVNVENAAYPSGLCAERNALFSSITY
  GFIPGKIQEIHILANTKEFIKPCAACLQVMIELMEYDADVYLYSITGAVEKRKLVEFLPL
  AFRKEFLN
• Function: This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
• KEGG Pathway:
  Metabolic pathways (mhr01100)
  Pyrimidine metabolism (mhr00240)

Molecular Interaction Atlas (MIA) of This DME

4 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1]

Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
Cytarabine	Acute lymphoblastic leukaemia [2A85]	Approved	Km = 6172 microM	[1]
Gemcitabine	Anterior urethra cancer []	Approved	Km = 2586 microM	[1]

References

• [1] Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.