Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEZO4N3)

DME Name	UDP-glucuronosyltransferase 1A7 (UGT1A7)
Synonyms	UDP-glucuronosyltransferase family 1 member A7; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1-7; UDPGT 1-7; UGT-1G; UGT1*7; UGT1-07; UGT1.7; UGT1A7; UGT1G
Gene Name	UGT1A7
UniProt ID	UD17_HUMAN
INTEDE ID	DME0065
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	54577
EC Number	EC: 2.4.1.17 Transferase Glycosyltransferases Hexosyltransferase EC: 2.4.1.17
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Function	This enzyme is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
KEGG Pathway	Ascorbate and aldarate metabolism (hsa00053 ) Chemical carcinogenesis (hsa05204 ) Drug metabolism - cytochrome P450 (hsa00982 ) Drug metabolism - other enzymes (hsa00983 ) Metabolic pathways (hsa01100 ) Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) Pentose and glucuronate interconversions (hsa00040 ) Porphyrin and chlorophyll metabolism (hsa00860 ) Retinol metabolism (hsa00830 ) Steroid hormone biosynthesis (hsa00140 )
Reactome Pathway	Glucuronidation (R-HSA-156588 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1]
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1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]
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1 Patented Agent(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[2]
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3 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[2]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[2]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[2]
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Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
Chrysin	Discovery agent [N.A.]	Investigative	Km = 0.004 microM	[2]
phloretin	Discovery agent [N.A.]	Investigative	Km = 0.0068 microM	[2]
EUGENOL	Discovery agent [N.A.]	Patented	Km = 0.0084 microM	[2]
Curcumin	Solid tumour/cancer [2A00-2F9Z]	Phase 3	Km = 0.1 microM	[2]

References

1	Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85.
2	Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.