Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT06I7G2)

DOT Name	Soluble TNF receptor II (CRMB1)
Synonyms	Cytokine response-modifying protein B
Gene Name	CRMB1
UniProt ID	CRMB_CAMPM
Pfam ID	PF07190 ; PF00020
Sequence	MKSVLYSYILFLSCIIINGRDVTPYAPSNGKCKDNEYKRHNLCCLSCPPGTYASRLCDSK TNTQCTPCGSGTFTSRNNHLPACLSCNGRCDSNQVETRSCNTTHNRICECSPGYYCILKG SSGCKACVSQTKCGIGYGVSGHTSAGDVICSPCGLGTYSRTVSSADKCEPVPSNTFNYID VEINLYPVNDTSCTRTTTTGISESISTSELTITMNHKDCDPVFREEYFSVLNKVATSGFF TGENRYQNISKVCTLNFEIKCNNKGSSSKQLTKAKNDDGIMPHSETVTLVGDCLSSVDIY ILYSNTNTQDYETDTISYHAGNVLDVDSHMPGSCDIHKLITNSKPTHFL
Function	Inhibits host immune defense by binding to host TNF and various chemokines in the extracellular space. Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines).

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Fluorouracil	DMUM7HZ	Approved	Soluble TNF receptor II (CRMB1) increases the Apoptosis ADR of Fluorouracil.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.