Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0RTOI8)

• DOT Name: GTP-binding protein REM 2 (REM2)
• Synonyms: Rad and Gem-like GTP-binding protein 2
• Gene Name: REM2
• UniProt ID: REM2_HUMAN
• PDB ID: 3CBQ
• Pfam ID: PF00071
• Sequence:
  MHTDLDTDMDMDTETTALCPSGSRRASPPGTPTPEADATLLKKSEKLLAELDRSGLPSAP
  GAPRRRGSMPVPYKHQLRRAQAVDELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLV
  GESGVGKSTLAGTFGGLQGDSAHEPENPEDTYERRIMVDKEEVTLVVYDIWEQGDAGGWL
  RDHCLQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVS
  LEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPA
  PPARRESLTKKAKRFLANLVPRNAKFFKQRSRSCHDLSVL
• Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

Molecular Interaction Atlas (MIA) of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the expression of GTP-binding protein REM 2 (REM2).	[1]
Methotrexate	DM2TEOL	Approved	Methotrexate decreases the expression of GTP-binding protein REM 2 (REM2).	[2]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of GTP-binding protein REM 2 (REM2).	[3]

References

• [1] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [2] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [3] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.