Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OT2J8U0Q)
| DOT Name | COP9 signalosome complex subunit 9 (COPS9) | ||||
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| Synonyms | CSN acidic protein; CSNAP; Myeloma-overexpressed gene 2 protein | ||||
| Gene Name | COPS9 | ||||
| UniProt ID | |||||
| 3D Structure | |||||
| Pfam ID | |||||
| Sequence |
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
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| Function |
[Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation; [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.
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Molecular Interaction Atlas (MIA) of This DOT
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4 Drug(s) Affected the Gene/Protein Processing of This DOT
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References