Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT2NCHGK)

DOT Name Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29)
Synonyms TIM29
Gene Name TIMM29
UniProt ID
TIM29_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
7CGP
Pfam ID
PF10171
Sequence
MAAAALRRFWSRRRAEAGDAVVAKPGVWARLGSWARALLRDYAEACRDASAEARARPGRA
AVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRNRESEAFVQRLLWLRGRG
RLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMR
DCDINDDEFLHLPAHLRVVGPQQLHSETNERLFDEKYKPVVLTDDQVDQALWEEQVLQKE
KKDRLALSQAHSLVQAEAPR
Function
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
4 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29). [1]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate decreases the expression of Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29). [2]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29). [3]
Urethane DM7NSI0 Phase 4 Urethane increases the expression of Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29). [4]
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References

1 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
4 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.