Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT42QOFG)

DOT Name A-kinase anchor protein 3 (AKAP3)
Synonyms
AKAP-3; A-kinase anchor protein 110 kDa; AKAP 110; Cancer/testis antigen 82; CT82; Fibrous sheath protein of 95 kDa; FSP95; Fibrousheathin I; Fibrousheathin-1; Protein kinase A-anchoring protein 3; PRKA3; Sperm oocyte-binding protein
Gene Name AKAP3
Related Disease
Colon cancer ( )
Colon carcinoma ( )
Hepatocellular carcinoma ( )
Lung cancer ( )
Lung carcinoma ( )
Ovarian cancer ( )
Ovarian neoplasm ( )
Testicular cancer ( )
Breast cancer ( )
Breast carcinoma ( )
Epithelial ovarian cancer ( )
Neoplasm ( )
Spermatogenic failure 82 ( )
UniProt ID
AKAP3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF05716
Sequence
MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSWLRRDLEKSTAEFQDVR
FKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMTHKEIPCQGPRAQLGNGSS
VDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLYMGNEPTPTKSLSKIASELVN
ETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSF
FYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMMVSI
MKTLKIQVKDTTIATILLKKVLLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKR
TVFSHGSQKATDIMDAMLRKLYNVMFAKKVPEHVRKAQDKAESYSLISMKGMGDPKNRNV
NFAMKSETKLREKMYSEPKSEEETCAKTLGEHIIKEGLTLWHKTQQKECKSLGFQHAAFE
APNTQRKPASDISFEYPEDIGNLSLPPYPPEKPENFMYDSDSWAEDLIVSALLLIQYHLA
QGGRRDARSFVEAAGTTNFPANEPPVAPDESCLKSAPIVGDQEQAEKKDLRSVFFNFIRN
LLSETIFKRDQSPEPKVPEQPVKEDRKLCERPLASSPPRLYEDDETPGALSGLTKMAVSQ
IDGHMSGQMVEHLMNSVMKLCVIIAKSCDASLAELGDDKSGDASRLTSAFPDSLYECLPA
KGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWV
AASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCSVGEVLQSVLRYEKERQLNEAVGNV
TPLQLLDWLMVNL
Function Has a role in the maintenance of acrosome structure. May function as a regulator of both spermatozoa motility and head-associated functions such as capacitation and the acrosome reaction.
Tissue Specificity Testis specific; only expressed in spermatids.

Molecular Interaction Atlas (MIA) of This DOT

13 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Colon cancer DISVC52G Strong Altered Expression [1]
Colon carcinoma DISJYKUO Strong Altered Expression [1]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [1]
Lung cancer DISCM4YA Strong Altered Expression [1]
Lung carcinoma DISTR26C Strong Altered Expression [1]
Ovarian cancer DISZJHAP Strong Altered Expression [1]
Ovarian neoplasm DISEAFTY Strong Altered Expression [1]
Testicular cancer DIS6HNYO Strong Biomarker [1]
Breast cancer DIS7DPX1 moderate Biomarker [2]
Breast carcinoma DIS2UE88 moderate Biomarker [2]
Epithelial ovarian cancer DIS56MH2 moderate Altered Expression [3]
Neoplasm DISZKGEW moderate Altered Expression [2]
Spermatogenic failure 82 DISCAJL9 Limited Unknown [4]
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⏷ Show the Full List of 13 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of A-kinase anchor protein 3 (AKAP3). [5]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of A-kinase anchor protein 3 (AKAP3). [6]
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References

1 Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma.Oncol Rep. 2012 Nov;28(5):1792-8. doi: 10.3892/or.2012.2002. Epub 2012 Aug 30.
2 AKAP3 correlates with triple negative status and disease free survival in breast cancer.BMC Cancer. 2015 Oct 12;15:681. doi: 10.1186/s12885-015-1668-0.
3 A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer.Gynecol Oncol. 2005 Oct;99(1):183-8. doi: 10.1016/j.ygyno.2005.06.006.
4 Mutation analysis in patients with total sperm immotility. J Assist Reprod Genet. 2015 Jun;32(6):893-902. doi: 10.1007/s10815-015-0474-6. Epub 2015 Apr 16.
5 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
6 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.