Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OT48VJ65)
DOT Name | Retinol dehydrogenase 13 (RDH13) | ||||
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Synonyms | EC 1.1.1.300; Short chain dehydrogenase/reductase family 7C member 3 | ||||
Gene Name | RDH13 | ||||
UniProt ID | |||||
3D Structure | |||||
EC Number | |||||
Pfam ID | |||||
Sequence |
MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELAR
RGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI LINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAG HIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRH TGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEA EDEEVARRLWAESARLVGLEAPSVREQPLPR |
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Function | Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity toward steroids. | ||||
Tissue Specificity | Widely expressed . In the retina, detected in the inner segment of the photoreceptor cells. Weak signals are observed in a small population of inner nuclear neurons and the inner plexiform layer . | ||||
KEGG Pathway | |||||
Reactome Pathway | |||||
Molecular Interaction Atlas (MIA) of This DOT
Molecular Interaction Atlas (MIA) | |||||||||||||||||||||||||||||||||||||||||||||
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5 Drug(s) Affected the Gene/Protein Processing of This DOT
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
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References