Details of Drug Off-Target (DOT)
General Information of Drug Off-Target (DOT) (ID: OT4T2BS1)
DOT Name | Insulin-like growth factor-binding protein 3 receptor (TMEM219) | ||||
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Synonyms | IGFBP-3R; Transmembrane protein 219 | ||||
Gene Name | TMEM219 | ||||
UniProt ID | |||||
3D Structure | |||||
Pfam ID | |||||
Sequence |
MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSF
LRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGS SAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVS VWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL |
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Function | Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. | ||||
Tissue Specificity | Widely expressed in normal tissues but suppressed in prostate and breast tumor. | ||||
Reactome Pathway | |||||
Molecular Interaction Atlas (MIA) of This DOT
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
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4 Drug(s) Affected the Gene/Protein Processing of This DOT
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References