Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT959L3E)

• DOT Name: Doublesex- and mab-3-related transcription factor C2 (DMRTC2)
• Gene Name: DMRTC2
• UniProt ID: DMRTD_HUMAN
• Pfam ID: PF00751 ; PF15791
• Sequence:
  MEPSDMPAGYHCPLDSAPWDETRDPQSTELIPRRAISRSPTCARCRNHGVTAHLKGHKRL
  CLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNHFRKGTTQP
  QVPSGKENIAPQPQTPHGAVLLAPTPPGKNSCGPLLLSHPPEASPLSWTPVPPGPWVPGH
  WLPPGFSMPPPVVCRLLYQEPAVSLPPFPGFDPGTSLQLPTHGPFTTCPGSHPVLTAPLS
  GEPQGPPSQPRTHSTLILQPCGTPDPLQLQPQASGASCLARTSGPSEWQLQQEAAEALVG
  LKDSSQAPRVTPSVPPNPAWISLLHPCGPPAPAGGRGFQPVGPCLRPSPAPSVALHIGRL
  GSISLLS
• Function: May be involved in sexual development.
• Tissue Specificity: Expressed in testis and pancreas.

Molecular Interaction Atlas (MIA) of This DOT

This DOT Affected the Drug Response of 2 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Temozolomide	DMKECZD	Approved	Doublesex- and mab-3-related transcription factor C2 (DMRTC2) affects the response to substance of Temozolomide.	[2]
DTI-015	DMXZRW0	Approved	Doublesex- and mab-3-related transcription factor C2 (DMRTC2) affects the response to substance of DTI-015.	[2]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Doublesex- and mab-3-related transcription factor C2 (DMRTC2).	[1]

References

• [1] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [2] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.