Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT96LFJH)

DOT Name Pre-mRNA-splicing factor CWC25 homolog (CWC25)
Synonyms Coiled-coil domain-containing protein 49; Spliceosome-associated protein homolog CWC25
Gene Name CWC25
UniProt ID
CWC25_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
5YZG; 6ZYM
Pfam ID
PF10197 ; PF12542
Sequence
MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDV
GAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFA
PSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKK
EKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGL
QGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSK
LHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERL
NILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEK
NFMKR
Function Involved in pre-mRNA splicing as component of the spliceosome.
Reactome Pathway
mRNA Splicing - Major Pathway (R-HSA-72163 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
6 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [1]
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [2]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [3]
Methotrexate DM2TEOL Approved Methotrexate decreases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [4]
Epigallocatechin gallate DMCGWBJ Phase 3 Epigallocatechin gallate decreases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [5]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 decreases the expression of Pre-mRNA-splicing factor CWC25 homolog (CWC25). [5]
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⏷ Show the Full List of 6 Drug(s)

References

1 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
2 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
3 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
4 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
5 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.