Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTAC32TJ)

DOT Name	SPEG neighbor protein (SPEGNB)
Gene Name	SPEGNB
UniProt ID	SPEGN_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF07679 ; PF00612
Sequence	MSKAAPAKKPVAVAPAPGCTLDINDPQVQSAAIRIQASYRGHRSRKELREKGPPRVLEPL KDVVLIEGSAAKLTCRISAFPDPFIRWSKDGKELRDGPKYRYVFEDPDVVALVVRDGELA DLGQYSINVTNPFGQCSDSARILVEVPTKIQKGPDNTKARKGTTVTLTAEILGEPAPDVG WTKDGEDIEEDDRVFFEIGSTTTTLTIRRATPQDSGKYEVYVENSLGMDQSFARVDVA

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Triclosan	DMZUR4N	Approved	Triclosan decreases the expression of SPEG neighbor protein (SPEGNB).	[1]
Niclosamide	DMJAGXQ	Approved	Niclosamide increases the expression of SPEG neighbor protein (SPEGNB).	[2]
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References

1	Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
2	Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.