| DOT Name |
General transcription factor IIE subunit 1 (GTF2E1)
|
| Synonyms |
General transcription factor IIE 56 kDa subunit; Transcription initiation factor IIE subunit alpha; TFIIE-alpha |
| Gene Name |
GTF2E1
|
| UniProt ID |
|
| 3D Structure |
|
| PDB ID |
1VD4 ; 2JTX ; 2RNQ ; 2RNR ; 5GPY ; 5IY6 ; 5IY7 ; 5IY8 ; 5IY9 ; 5IYA ; 5IYB ; 5IYC ; 5IYD ; 6O9L ; 7EG9 ; 7EGA ; 7EGB ; 7EGC ; 7ENA ; 7ENC ; 7LBM ; 7NVR ; 7NVS ; 7NVT ; 7NVU ; 7NVV ; 7NVW ; 7NVX ; 7NVY ; 7NVZ ; 7NW0 ; 8BVW ; 8BYQ ; 8GXQ ; 8GXS ; 8WAK ; 8WAL ; 8WAN ; 8WAO ; 8WAP ; 8WAQ ; 8WAR ; 8WAS
|
| Pfam ID |
PF08271
; PF11521
; PF02002
|
| Sequence |
MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQLR
SVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERD
STNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARF
NEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDHAATTAGAASLAGGHHREAWA
TKGPSYEDLYTQNVVINMDDQEDLHRASLEGKSAKERPIWLRESTVQGAYGSEDMKEGGI
DMDAFQEREEGHAGPDDNEEVMRALLIHEKKTSSAMAGSVGAAAPVTAANGSDSESETSE
SDDDSPPRPAAVAVHKREEDEEEDDEFEEVADDPIVMVAGRPFSYSEVSQRPELVAQMTP
EEKEAYIAMGQRMFEDLFE
|
| Function |
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
|
| KEGG Pathway |
- Basal transcription factors (hsa03022 )
- Viral carcinogenesis (hsa05203 )
|
| Reactome Pathway |
- RNA Polymerase II HIV Promoter Escape (R-HSA-167162 )
- Transcription of the HIV genome (R-HSA-167172 )
- RNA Polymerase II Pre-transcription Events (R-HSA-674695 )
- RNA polymerase II transcribes snRNA genes (R-HSA-6807505 )
- RNA Polymerase II Promoter Escape (R-HSA-73776 )
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (R-HSA-73779 )
- RNA Polymerase II Transcription Initiation (R-HSA-75953 )
- RNA Polymerase II Transcription Initiation And Promoter Clearance (R-HSA-76042 )
- HIV Transcription Initiation (R-HSA-167161 )
|
|
|
|
|
|
|
