General Information of Drug Off-Target (DOT) (ID: OTAZ1LEC)

DOT Name Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2)
Synonyms 40S ribosomal protein S4, Y isoform 2
Gene Name RPS4Y2
UniProt ID
RS4Y2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF16121 ; PF00467 ; PF00900 ; PF08071
Sequence
MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIVFLRNRLKYALTGDE
VKKICMQHFLKIDGKVRVDITYPAGFIDVISIEKTGEHFRLVYNTKGCFAVHRITVEEAK
YKLCKVRKITVGTKGIPHLVTHDARTIRYPDPLIKVNDTVQIDLGTGKITSFIKFDTGNV
CMVIAGANLGRVGVITNRERHPGSCDVVHVKDANGNSFATRISNIFVIGNGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG
KEGG Pathway
Ribosome (hsa03010 )
Coro.virus disease - COVID-19 (hsa05171 )
Reactome Pathway
Peptide chain elongation (R-HSA-156902 )
SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 )
Viral mRNA Translation (R-HSA-192823 )
Selenocysteine synthesis (R-HSA-2408557 )
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )
Translation initiation complex formation (R-HSA-72649 )
Formation of a pool of free 40S subunits (R-HSA-72689 )
Formation of the ternary complex, and subsequently, the 43S complex (R-HSA-72695 )
Ribosomal scanning and start codon recognition (R-HSA-72702 )
GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
Eukaryotic Translation Termination (R-HSA-72764 )
Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )
Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 )
SARS-CoV-1 modulates host translation machinery (R-HSA-9735869 )
SARS-CoV-2 modulates host translation machinery (R-HSA-9754678 )
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 )
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 )
L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2). [1]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2). [2]
Temozolomide DMKECZD Approved Temozolomide increases the expression of Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2). [3]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2). [4]
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References

1 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
2 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
3 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.