Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTBW7AR4)

DOT Name	Ankyrin repeat domain-containing protein 7 (ANKRD7)
Synonyms	Testis-specific protein TSA806
Gene Name	ANKRD7
Related Disease	Alcohol dependence ( ) Non-small-cell lung cancer ( )
UniProt ID	ANKR7_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF12796
Sequence	MNKLFSFWKRKNETRSQGYNLREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYR TPLHLACANGHTDVVLFLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDL RDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEK GADVNASDNYQRTALILAVSGEPPCLVKLLLQQGVELCYEGIVDSQLRNMFISMVLLHRY PQFTASHGKKKHAK
Tissue Specificity	Testis specific.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance
Alcohol dependence	DIS4ZSCO	Strong	Biomarker	[1]
Non-small-cell lung cancer	DIS5Y6R9	Strong	Genetic Variation	[2]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Ankyrin repeat domain-containing protein 7 (ANKRD7).	[3]
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References

1	ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chin Med J (Engl). 2012 Mar;125(6):1127-34.
2	Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.Clin Cancer Res. 2012 Oct 1;18(19):5507-14. doi: 10.1158/1078-0432.CCR-12-1202. Epub 2012 Aug 7.
3	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.